ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Monitoring Allograft Injury

November 04, 2023 | 02:00 PM - 04:00 PM

Location: Room 120, Pennsylvania Convention Center

Session Description

Accurate and timely detection of allograft rejection and effective treatment are essential for long-term survival of kidney transplants. Although transplant biopsy remains the standard for diagnosis of rejection, recent advances in genomics technology and spatial transcriptomic to detect expression patterns of thousands of genes simultaneously using blood, urine, and kidney biopsies have shown to provide valuable information in monitoring kidney transplant patients for allograft rejection. In this panel, four speakers discuss novel biomarkers for detection of kidney allograft injury.

Learning Objective(s)

  • Explain how urinary gene transcripts by mRNA or detection of exosomes can provide information for the diagnosis of acute rejection or immune quiescence
  • Summarize how molecular assessment of kidney biopsies by microarrays has been recently introduced to improve diagnostic accuracy of different types of rejection
  • Outline how blood gene transcripts and donor-derived cell-free DNA can be used to monitor allograft injury
  • Discuss how spatial transcriptomics of graft biopsies can be used when monitoring kidney transplant patients for allograft injury

Learning Pathway(s)

  • Kidney Transplantation