Basic/Clinical Science Session
Organoids with PKD: Defining What They Are and What They Can Do for Us
November 02, 2023 | 02:00 PM - 04:00 PM
Location: Room 105, Pennsylvania Convention Center
Session Description
In this session, participants hear from researchers who have designed organoid systems that are affected by PKD genotypes. Participants hear about different approaches using human cells from urine, adult kidneys, or pluripotent stem cells, with help of bioengineering, and learn what human kidney organoids or tubuloids have taught us about the biology of in vitro cell culture, cysts, treatments, and identification of cell types capable of forming these structures.
Learning Objective(s)
- Discuss advances and limitations of modeling kidneys in 3D culture
- Evaluate how bioengineering approaches can contribute to improving kidney organoids and the conclusions we can draw from them
- Specify an approach to multiplex organoids to test therapies
- Describe the cellular basis of kidney tubuloids derived from adult human cells
Learning Pathway(s)
- Genetic Diseases and Development
- Kidney Biology and Physiology
Moderators
Presentations
- Advances, Limitations, and New Hypotheses from Organoid Modeling of Ciliopathy and ADPKD Genes
02:00 PM - 02:30 PM
- Organoid-on-a-Chip Model of Human ARPKD Reveals Mechanosensing
02:30 PM - 03:00 PM
- Organoid Model of ADPKD for Mechanism and Drug Screening
03:00 PM - 03:30 PM
- Adult Human Kidney Organoids Originate from CD24+ Cells and Can Model ADPKD
03:30 PM - 04:00 PM