Basic/Clinical Science Session
Chloride Channels: Physiologic and Pathophysiologic Relevance
November 02, 2023 | 10:30 AM - 12:30 PM
Location: Room 114 (Nutter Theatre), Pennsylvania Convention Center
Session Description
Chloride channels play an important role of electrolyte homeostasis. Mutations of chloride channels cause renal salt wasting and cyst formation. This session focuses on the physiologic and pathophysiologic relevance of chloride channels and new findings of CIC channels underlying disease processes. The session also discusses the potential drug candidates on CIC channel/transporters and their clinical implications.
Learning Objective(s)
- Discuss the physiologic and pathophysiologic roles of CIC channels
- Explain the novel role of CIC5 in renal cyst development
- Describe the novel role of CICK2 in renal medulla development and salt wasting
- Outline the potential drug candidates for chloride channels/transporters
Learning Pathway(s)
- Fluid‚ Electrolyte‚ and Acid-Base Disorders
- Kidney Biology and Physiology
Moderators
Presentations
- Novel Roles of CIC-Kb Chloride Channel in Collecting Duct Intercalated Cells
10:30 AM - 11:00 AM
- Electrogenic Exchanger ClC5 as a Novel Player in Renal Cysts in Tuberous Sclerosis
11:00 AM - 11:30 AM
- Impairment in Renal Medulla Development Underlies Salt Wasting in ClCK2 Channel Deficiency
11:30 AM - 12:00 PM
- Chloride Transport Modulators as Drug Candidates
12:00 PM - 12:30 PM