Kidney Week

Basic/Clinical Science Session

Novel Roles of Channels and Transporters in Kidney Diseases and CVD

November 04, 2023 | 02:00 PM - 04:00 PM

Location: Room 111, Pennsylvania Convention Center

Session Description

Channels and/or transporters in the kidneys and the cardiovascular systems play a significant role in maintaining BP and electrolyte balance. Functional alterations of channels and/or transporters will lead to different disease phenotypes. This session focuses on the novel modulators of channels and/or transporters and their associated disease phenotypes in the kidneys and cardiovascular systems.

Learning Objective(s)

• Describe the novel role of histamine receptors in ENaC regulation
• Explain the new target of SGLT2 inhibitors in the heart
• Examine the novel role of the Piezo1 channel in kidney fibrosis
• Discuss the novel urea transporter role in cardiomyopathy in CKD

Learning Pathway(s)

• Fluid‚ Electrolyte‚ and Acid-Base Disorders
• Hypertension and Cardiorenal Disorders

Moderators

• Lei Wang, PhD
• Owen M. Woodward, PhD

Presentations

• Novel Role of Histamine Receptors in the Regulation of Renal Epithelial Sodium Channel (ENaC)
  02:00 PM - 02:30 PM
  
  • Daria Ilatovskaya, MS, PhD
  Daria Ilatovskaya, MS, PhD

Novel Role of Histamine Receptors in the Regulation of Renal Epithelial Sodium Channel (ENaC)

November 04, 2023 | 02:00 PM - 02:30 PM

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• Targeting the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Calcium: A New Therapeutic Approach to PKD
  02:30 PM - 03:00 PM
  
  • Liudmila Cebotaru, MD
  Liudmila Cebotaru, MD

Targeting the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Calcium: A New Therapeutic Approach to PKD

November 04, 2023 | 02:30 PM - 03:00 PM

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• Mechanosensitive Piezo1 Channels Mediate Kidney Fibrosis
  03:00 PM - 03:30 PM
  
  • Weidong Wang, MD, PhD
  Weidong Wang, MD, PhD

Mechanosensitive Piezo1 Channels Mediate Kidney Fibrosis

November 04, 2023 | 03:00 PM - 03:30 PM

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• Inhibition of Urea Transporter Ameliorates Uremic Cardiomyopathy in CKD
  03:30 PM - 04:00 PM
  
  • Jeff M. Sands, MD, FASN
  Jeff M. Sands, MD, FASN

Inhibition of Urea Transporter Ameliorates Uremic Cardiomyopathy in CKD

November 04, 2023 | 03:30 PM - 04:00 PM

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