ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Proteinuria and Megalin: Form Meets Function

November 04, 2023 | 10:30 AM - 12:30 PM

Location: Room 114 (Nutter Theatre), Pennsylvania Convention Center

Session Description

This session highlights advances in our understanding of how filtered protein is handled in the proximal tubule (PT), with a focus on megalin, one of the major PT protein-scavenging receptors. Presentations include state-of-the-art insights into megalin's structure, endocytic trafficking, and role in AKI.

Learning Objective(s)

  • Explain how filtered proteins are processed by the PT endolysosomal system
  • Articulate how pH can change megalin structure and function
  • Describe the role of megalin endocytosis and recycling kinetics in filtered protein processing
  • Define the role of megalin in certain forms of AKI

Learning Pathway(s)

  • Kidney Biology and Physiology
  • Fluid‚ Electrolyte‚ and Acid-Base Disorders