Basic/Clinical Science Session
Proteinuria and Megalin: Form Meets Function
November 04, 2023 | 10:30 AM - 12:30 PM
Location: Room 114 (Nutter Theatre), Pennsylvania Convention Center
Session Description
This session highlights advances in our understanding of how filtered protein is handled in the proximal tubule (PT), with a focus on megalin, one of the major PT protein-scavenging receptors. Presentations include state-of-the-art insights into megalin's structure, endocytic trafficking, and role in AKI.
Learning Objective(s)
- Explain how filtered proteins are processed by the PT endolysosomal system
- Articulate how pH can change megalin structure and function
- Describe the role of megalin endocytosis and recycling kinetics in filtered protein processing
- Define the role of megalin in certain forms of AKI
Learning Pathway(s)
- Kidney Biology and Physiology
- Fluid‚ Electrolyte‚ and Acid-Base Disorders
Moderators
Presentations
- Overview of Filtered Protein Processing in the Proximal Tubule
10:30 AM - 11:00 AM
- Megalin Structure in Endosomes and at the Surface
11:00 AM - 11:30 AM
- Megalin Traffic and Albumin Uptake in Health and Disease
11:30 AM - 12:00 PM
- Megalin in Rhabdomyolysis-Induced AKI
12:00 PM - 12:30 PM