Basic/Clinical Science Session
Novel Mechanisms of Salt-Sensitive Hypertension
November 04, 2023 | 02:00 PM - 04:00 PM
Location: Room 118, Pennsylvania Convention Center
Session Description
Kidneys play a critical role in the pathogenesis of hypertension and target organ injury from hypertension. This session reviews multiple recent advances in identifying mechanisms contributing to the development of salt-sensitive hypertension, hypertension-mediated kidney injury, and potential therapeutic targets.
Learning Objective(s)
- Describe the mechanistic link between ENaC, inflammation, and hypertension
- Outline the role of renal Nox-induced oxidative stress and mitochondrial dysfunction in the development of hypertension
- Explain how accelerated lysine metabolism protects kidneys from hypertensive injury
- Discuss the relationship between magnesium TRPM7 channels and kidney injury caused by salt loading and aldosterone
Learning Pathway(s)
- Hypertension and Cardiorenal Disorders
- Kidney Biology and Physiology
Moderators
Presentations
- ENaC-Dependent Inflammasomes in Hypertension
02:00 PM - 02:30 PM
- Mitochondrial Dysfunction in the Pathogenesis of Salt-Sensitive Hypertension
02:30 PM - 03:00 PM
- Lysine Metabolism and Kidney Protection in Salt-Sensitive Hypertension
03:00 PM - 03:30 PM
- Epigenetic Mechanisms of Salt-Sensitive Hypertension
03:30 PM - 04:00 PM