ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Novel Mechanisms of Salt-Sensitive Hypertension

November 04, 2023 | 02:00 PM - 04:00 PM

Location: Room 118, Pennsylvania Convention Center

Session Description

Kidneys play a critical role in the pathogenesis of hypertension and target organ injury from hypertension. This session reviews multiple recent advances in identifying mechanisms contributing to the development of salt-sensitive hypertension, hypertension-mediated kidney injury, and potential therapeutic targets.

Learning Objective(s)

  • Describe the mechanistic link between ENaC, inflammation, and hypertension
  • Outline the role of renal Nox-induced oxidative stress and mitochondrial dysfunction in the development of hypertension
  • Explain how accelerated lysine metabolism protects kidneys from hypertensive injury
  • Discuss the relationship between magnesium TRPM7 channels and kidney injury caused by salt loading and aldosterone

Learning Pathway(s)

  • Hypertension and Cardiorenal Disorders
  • Kidney Biology and Physiology