Kidney Week

Clinical Practice Session

Don't Let It Go to Your Head: Hyponatremia and the Brain

November 06, 2025 | 10:30 AM - 12:30 PM

Location: Room 320A, Convention Center

Session Description

Plasma sodium concentration is a key determinant of plasma tonicity, which, in turn, influences cell volume. When extracellular tonicity drops, cells may swell if the mechanisms that regulate cell volume are insufficient. This session explores the pathogenesis, diagnosis, and treatment of brain complications associated with hyponatremia and its correction.

Learning Objective(s)

• Describe cellular mechanisms of brain adaptation to hyponatremia and its correction
• Identify best practices for the use of hypertonic saline in patients with hyponatremic encephalopathy
• Evaluate neurocognitive deficits associated with mild, chronic hyponatremia
• Discuss plasma sodium correction limits in patients with chronic hyponatremia based on their risk for neurological complications

Learning Pathway(s)

• Fluid‚ Electrolyte‚ and Acid-Base Disorders

Moderators

• Michael L. Moritz, MD, FASN
• Sagar U. Nigwekar, MD

Presentations

• Mechanisms of Brain Cell Adaptation to Hyponatremia and Its Correction
  10:30 AM - 10:50 AM
  
  • Fabrice Gankam Kengne, MD, PhD

Mechanisms of Brain Cell Adaptation to Hyponatremia and Its Correction

November 06, 2025 | 10:30 AM - 10:50 AM

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• Diagnosis and Management of Hyponatremic Encephalopathy
  10:50 AM - 11:10 AM
  
  • Amy Yau, MD, FASN

Diagnosis and Management of Hyponatremic Encephalopathy

November 06, 2025 | 10:50 AM - 11:10 AM

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• Neurocognitive Deficits in Mild, Chronic Hyponatremia
  11:10 AM - 11:30 AM
  
  • Helbert Rondon Berrios, MD, MS, FASN

Neurocognitive Deficits in Mild, Chronic Hyponatremia

November 06, 2025 | 11:10 AM - 11:30 AM

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• Osmotic Demyelination Syndrome: From Discovery to Denial
  11:30 AM - 11:50 AM
  
  • Richard H. Sterns, MD

Osmotic Demyelination Syndrome: From Discovery to Denial

November 06, 2025 | 11:30 AM - 11:50 AM

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• Panel Discussion
  11:50 AM - 12:30 PM
  

Panel Discussion

November 06, 2025 | 11:50 AM - 12:30 PM

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