Basic/Clinical Science Session
The Far Side of the Nephron: New Insights into Basolateral Transport and Signaling
November 07, 2025 | 02:00 PM - 04:00 PM
Location: Room 320A, Convention Center
Session Description
Hydromineral and acid-base balance critically depend on the orchestrated transport of ions and water through apical and basolateral membranes of renal epithelial cells. Current understanding of basolateral channels, transporters, receptors, and downstream signaling is limited. This session reviews recent discoveries in this area pertaining to renal sodium, potassium, acid-base handling, and BP control and discusses how basolateral transporters and receptors can be targeted to combat disease.
Learning Objective(s)
- Explain the physiological role of basolateral transporters and signaling for renal electrolyte and acid-base handling
- Describe how defects in basolateral ion transport contribute to kidney diseases
- Summarize recent advances in the understanding of the basolateral transport and signaling
Learning Pathway(s)
- Kidney Biology and Physiology
- Fluid‚ Electrolyte‚ and Acid-Base Disorders
Moderators
Presentations
- PIEZO1 Channel Is a Critical Determinant of Flow-Induced Potassium Secretion in the Distal Nephron
02:00 PM - 02:30 PM
- Pendrin-Positive Intercalated Cells in Renal Salt Handling and BP Control
02:30 PM - 03:00 PM
- Regulation of Ion and Acid-Base Transport in the Distal Nephron by ClC-K2 and Kir4.1/5.1 Channels
03:00 PM - 03:30 PM
- SGLT2 Inhibitors Attenuate Renal Proximal Tubulopathy in Fanconi-Bickel Syndrome
03:30 PM - 04:00 PM