Kidney Week

Basic/Clinical Science Session

Novel Therapeutic Approaches and Pathways for Phosphate and Fibroblast Growth Factor 23 Regulation

November 06, 2025 | 02:00 PM - 04:00 PM

Location: Room 370A, Convention Center

Session Description

Disordered mineral metabolism, including alterations in phosphate and fibroblast growth factor 23 (FGF23), are strongly associated with adverse outcomes in kidney diseases. Current treatment options are limited, in part because of incomplete understanding of the underlying physiology of phosphate and FGF23 regulation in health and disease. Emerging insights along these lines have the potential to identify new therapeutic opportunities relevant to AKI, CKD, and ESKD.

Learning Objective(s)

• Describe how vitamin D regulation in the intestine can affect systemic mineral metabolism
• Explain how systemic vs. bone effects of phosphate can be separated
• Distinguish the role of phosphate in AKI and its complications
• Describe the potential adverse role for calciprotein particles in CKD and ESKD

Learning Pathway(s)

• Bones‚ Stones‚ and Mineral Metabolism

Moderators

• Wei Chen, MD, MS, FASN
• Daniel Edmonston, MD, MHS

Presentations

• Differential Impacts of Intestinal vs. Renal Vitamin D Metabolism
  02:00 PM - 02:30 PM
  
  • Michaela A.A. Fuchs, PhD

Differential Impacts of Intestinal vs. Renal Vitamin D Metabolism

November 06, 2025 | 02:00 PM - 02:30 PM

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• Glycerol-3-Phosphate Metabolism in CKD-MBD
  02:30 PM - 03:00 PM
  
  • Petra Simic, MD, PhD

Glycerol-3-Phosphate Metabolism in CKD-MBD

November 06, 2025 | 02:30 PM - 03:00 PM

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• Phosphate Restriction and AKI
  03:00 PM - 03:30 PM
  
  • Daniela Egli-Spichitg, PhD

Phosphate Restriction and AKI

November 06, 2025 | 03:00 PM - 03:30 PM

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• Calciprotein Particles in CKD and Its Complications
  03:30 PM - 04:00 PM
  
  • Makoto Kuro-o, MD, PhD

Calciprotein Particles in CKD and Its Complications

November 06, 2025 | 03:30 PM - 04:00 PM

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