Basic/Clinical Science Session
Small Molecules to Modulate CKD-MBD
November 08, 2025 | 02:00 PM - 04:00 PM
Location: Room 370A, Convention Center
Session Description
In parallel with growing knowledge about key molecular determinants of CKD-MBD, the development of small molecule agonists and antagonists that target these molecules is required for new treatments. This session provides emerging examples of approaches being used to identify and optimize these kinds of small molecules.
Learning Objective(s)
- Explain how salt-inducible kinases act downstream of PTH action in kidneys and bones
- Discuss the potential for mTOR inhibitors to affect parathyroid function
- Describe the complex effects of tubular sodium and phosphate absorption on CKD-MBD
- Explain how structural determination can inform drug discovery
Learning Pathway(s)
- Bones‚ Stones‚ and Mineral Metabolism
- Pharmacology
Moderators
Presentations
- Salt-Inducible Kinase Inhibitors in Bones and Kidneys
02:00 PM - 02:30 PM
- mTORC1 Inhibitors and the Parathyroid Glands
02:30 PM - 03:00 PM
- Inhibitors of Sodium and Phosphate Transport in the Kidneys
03:00 PM - 03:30 PM
- Structure-Based Discovery of Positive Allosteric Modulators for the Calcium-Sensing Receptor
03:30 PM - 04:00 PM