Kidney Week

Basic/Clinical Science Session

Unraveling the Mysteries of AKI: Therapeutic Strategies on the Horizon

November 07, 2025 | 02:00 PM - 04:00 PM

Location: General Assembly B, Convention Center

Session Description

Recent work has highlighted how adaptations in tubular, endothelial, and/or fibrotic remodeling drive pathogenic signaling after injury, culminating in the transition of AKI to CKD. This session reviews the latest developments in understanding these pathogenic cascades and explores potential therapeutic strategies to prevent disease progression. This session also discusses new findings of alterations in kidney physiology during spaceflight travel that have revealed unique physiological adaptations of the kidneys to extreme conditions.

Learning Objective(s)

• Explain the role of hypoxia in modulating endothelial responses during AKI and transition to CKD
• Explain the role of fibroblasts in regulating the kidney microenvironment to dictate AKI outcomes
• Describe acute and chronic changes in kidney physiology during spaceflight

Learning Pathway(s)

• AKI and Critical Care
• Kidney Biology and Physiology

Moderators

• Lisa M. Curtis, PhD
• Karl A. Nath, MBChB

Presentations

• Targeting Endothelial Metabolism to Enhance Kidney Repair
  02:00 PM - 02:30 PM
  
  • Pinelopi P. Kapitsinou, MD

Targeting Endothelial Metabolism to Enhance Kidney Repair

November 07, 2025 | 02:00 PM - 02:30 PM

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• Tubular Cell-Matrix Interactions in AKI: Role of the Fibroblast
  02:30 PM - 03:00 PM
  
  • Dong Zhou, MD, PhD

Tubular Cell-Matrix Interactions in AKI: Role of the Fibroblast

November 07, 2025 | 02:30 PM - 03:00 PM

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• Promoting Recovery During AKI with RNA Editing
  03:00 PM - 03:30 PM
  
  • Rick G. Schnellmann, PhD

Promoting Recovery During AKI with RNA Editing

November 07, 2025 | 03:00 PM - 03:30 PM

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• Space Travel and Cosmic Kidney Injury and Disease
  03:30 PM - 04:00 PM
  
  • Keith Siew, MSc, PhD

Space Travel and Cosmic Kidney Injury and Disease

November 07, 2025 | 03:30 PM - 04:00 PM

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