Kidney Week

Basic/Clinical Science Session

APOL1-Mediated Kidney Disease: A Blueprint for Precision Nephrology?

November 08, 2025 | 02:00 PM - 04:00 PM

Location: Room 360A, Convention Center

Session Description

Genetic discoveries have revolutionized our understanding of kidney diseases, and the discovery of APOL1 risk variants stands as a flagship breakthrough for the field. This dynamic session delves into the complex biology of APOL1-mediated kidney disease, from molecular mechanisms to clinical implications. Leading experts present cutting-edge insights into how APOL1 variants drive kidney injury, novel therapeutic strategies in development, and the broader impact on patient care. As targeted interventions become a reality, this session is a must-attend for anyone interested in the future of precision nephrology and health disparities in kidney diseases.

Learning Objective(s)

• Explain the mechanisms of APOL1-mediated kidney disease
• Assess the global epidemiology of APOL1-mediated kidney disease
• Describe the role of APOL1 genetic testing in the setting of kidney transplantation
• Summarize the latest treatments targeting APOL1-mediated kidney disease

Learning Pathway(s)

• Genetic Diseases and Development

Moderators

• Marva M. Moxey-Mims, MD, FASN
• Simone Sanna-Cherchi, MD

Presentations

• Mechanisms of APOL1-Mediated Kidney Disease
  02:00 PM - 02:30 PM
  
  • Martin Pollak, MD

Mechanisms of APOL1-Mediated Kidney Disease

November 08, 2025 | 02:00 PM - 02:30 PM

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• APOL1 in West Africa: Updates from the H3Africa Study
  02:30 PM - 03:00 PM
  
  • Ifeoma I. Ulasi, MBBS

APOL1 in West Africa: Updates from the H3Africa Study

November 08, 2025 | 02:30 PM - 03:00 PM

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• APOL1 and Kidney Transplantation: Impact on Donors and Recipients
  03:00 PM - 03:30 PM
  
  • Krista L. Lentine, MD, PhD, FASN

APOL1 and Kidney Transplantation: Impact on Donors and Recipients

November 08, 2025 | 03:00 PM - 03:30 PM

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• Therapeutic Targeting of APOL1-Mediated Kidney Disease
  03:30 PM - 04:00 PM
  
  • Opeyemi A. Olabisi, MD, PhD

Therapeutic Targeting of APOL1-Mediated Kidney Disease

November 08, 2025 | 03:30 PM - 04:00 PM

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