Kidney Week

Basic/Clinical Science Session

Mechanistic Insights on Urinary Stone Formation

November 09, 2025 | 09:30 AM - 11:30 AM

Location: Room 370A, Convention Center

Session Description

Both genetic and environmental factors contribute to stone risk. Ongoing research that examines a range of these factors, including common and rare genetic variation, frequently used medications, and urothelial bacteria, has the potential to improve understanding of kidney stone pathophysiology and therapeutic approaches.

Learning Objective(s)

• Explain how genetic variation contributes to the risk of kidney stone formation
• Identify key enzymes that could be targeted to affect oxalate metabolism
• Describe the impact of SGLT2 inhibitors on urinary calcium and uric acid levels
• Explain how urothelial bacterial populations can affect stone formation and be influenced by antibiotics

Learning Pathway(s)

• Bones‚ Stones‚ and Mineral Metabolism

Moderators

• Sonia Fargue, MD, PhD
• Anna L. Zisman, MD, FASN

Presentations

• Using Genome-Wide Association Studies to Define Genetic Risks for Mineral Metabolism and Nephrolithiasis
  09:30 AM - 10:00 AM
  
  • Sarah Howles, MD, PhD

Using Genome-Wide Association Studies to Define Genetic Risks for Mineral Metabolism and Nephrolithiasis

November 09, 2025 | 09:30 AM - 10:00 AM

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• Targeting Proline Dehydrogenase 2 to Reduce Oxalate Secretion
  10:00 AM - 10:30 AM
  
  • Lisa M Ellerby, PhD

Targeting Proline Dehydrogenase 2 to Reduce Oxalate Secretion

November 09, 2025 | 10:00 AM - 10:30 AM

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• SGLT2 Inhibitors and Calcium and Uric Acid Stones
  10:30 AM - 11:00 AM
  
  • Daniel G. Fuster, MD, FASN

SGLT2 Inhibitors and Calcium and Uric Acid Stones

November 09, 2025 | 10:30 AM - 11:00 AM

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• Antibiotics, Uropathogens, and Calcium Stone Formation
  11:00 AM - 11:30 AM
  
  • Aaron W. Miller, PhD

Antibiotics, Uropathogens, and Calcium Stone Formation

November 09, 2025 | 11:00 AM - 11:30 AM

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