Kidney Week

Educational Symposium

Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors, CVD, and Hyporesponsiveness to Erythropoiesis-Stimulating Agents in ESKD

November 06, 2025 | 12:45 PM - 01:45 PM

Location: Room TBD2, Hilton Americas-Houston

Session Description

Anemia is a common condition in patients with CKD that reduces quality of life and increases morbidity and mortality risk. Intravenous iron and erythropoiesis-stimulating agents (ESAs) have been the treatment mainstays for CKD-associated anemia. Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of oral medications to treat anemia in patients with ESKD.

CVD is a major component of anemia-related morbidity in ESKD, and through a diverse set of mechanisms, HIF-PHIs may have positive cardiac effects. In patients who become hyporesponsive to ESAs, HIF-PHIs provide an alternative means of treating anemia. This symposium discusses potential cardiovascular effects of HIF-PHIs and summarizes cardiovascular outcomes from clinical trials. Mechanisms of hyporesponsiveness to ESAs are also explored.

Support is provided by an educational grant from Akebia Therapeutics, Inc.

Learning Objective(s)

• Outline the mechanisms by which HIF-PHIs treat anemia in patients with kidney diseases
• Describe the cardiovascular effects of HIF-PHIs
• Explain the mechanisms underlying a poor response to ESAs

Learning Pathway(s)

• Dialysis
• Pharmacology

Moderator

• Marcello Tonelli, MD, MS, MSc

Presentations

• Introduction
  12:45 PM - 12:55 PM
  
  • Marcello Tonelli, MD, MS, MSc

Introduction

November 06, 2025 | 12:45 PM - 12:55 PM

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• Cardiovascular Effects of HIF-PHIs in ESKD
  12:55 PM - 01:15 PM
  
  • Diana I. Jalal, MD

Cardiovascular Effects of HIF-PHIs in ESKD

November 06, 2025 | 12:55 PM - 01:15 PM

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• Are HIF-PHIs the Solution to ESA Hyporesponsiveness in ESKD?
  01:15 PM - 01:35 PM
  
  • Mark Koury, MD

Are HIF-PHIs the Solution to ESA Hyporesponsiveness in ESKD?

November 06, 2025 | 01:15 PM - 01:35 PM

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• Q&A
  01:35 PM - 01:45 PM
  

Q&A

November 06, 2025 | 01:35 PM - 01:45 PM

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