Orson W. Moe, MD, BRCU Faculty
Orson W. Moe, MD, received his medical degree from the University of Toronto and is currently Professor of Mineral Metabolism, Internal Medicine and Physiology at the University of Texas Southwestern Medical Center, where he is a clinician, teacher, and researcher. His administrative duties include Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research. He is the holder of the Charles and Jane Pak Distinguished Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation.
Dr. Moe conducts both preclinical pathophysiology and patient-oriented research on renal physiology and metabolism, as well as epithelial biology. His research strives to cross from the level of the whole patient to animal and cell culture models, and down to single molecules. He is active in teaching at the undergraduate and post-graduate levels in his institution and also nationally and internationally.
Dr. Moe is the Co-Editor of Current Opinion in Nephrology and Hypertension: Pathophysiology and the textbook Seldin and Giebisch's The Kidney: Physiology and Pathophysiology. He also serves on the Editorial Board of Clinical Journal of AMerican Society of Nephrology. He is currently a member of the American Society of Clinical Research, American Association of Physicians, American Society of Nephrology, International Society of Nephrology, and American Physiologic Society.
Professor of Internal Medicine & Professor of Physiology
Director, Charles and Jane Pak Center of Mineral Metabolism and Clinical Research
University of Texas Southwestern Medical Center
Degrees/Training:
MD: Univ. Toronto, Toronto, Ontario, Canada 1982
Internship: Surgery, Univ. Toronto, Toronto, Ontario, Canada 1982-83
Internal Medicine Residency: Univ. Toronto, Toronto, Ontario, Canada 1983-86
Nephrology Fellowship: Univ. Toronto, Toronto, Ontario, Canada 1986-87
Post-Doc Research Training: Univ. Texas Southwestern Medical Center 1987-90
ASN Service:
Abstract Selection Committee (Member): 1991, 1993, 1998, 2002, 2004, 2005, 2006, 2007, 2008, 2010, 2012, 2013, 2015, 2017, 2020. Abstract Selection Committee (Section Chair): 2000, 2011, 2014, 2019. ASN Board Review Course and Update: 2004, 2005, 2012-15, 2017-18. ASN Annual Meeting Invited Lecture: 2005, 2006, 2009, 2010, 2013, 2015, 2018, 2019, 2021. Evaluation Committee for John P. Peters Award (Member): 2006-2009. Nominating Committee for Council (Member): 2010, 2019. Editorial Board J American Society Nephrology: 2009-2017
Basic Research Forum for Emerging Kidney Scientists (Mentor): 2019-2022.
Leadership positions:
On campus-UT Southwestern:
Division Chief, Nephrology. UTSouthwestern 2014-2021
Director, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research 2002-present
Director O'Brien Kidney Research Center: 2013-2022
Director NIDDK Training Grant: 2013-2022
Editor, Current Opinions Nephrology Hypertension: Pathophysiology: 1999-present
Editor, Textbook Seldin & Giebisch?s: The Kidney: 2012-present
Member of NIH study sections:
1995 ADPKD RFA Ad Hoc
1997 General Medicine B Ad Hoc
2002- NIDDK Program Projects Ad Hoc
2002-2003 General Medicine B
2003-2007 Cell & Molecular Biology Kidney
2010 NIDDK U34 and U01 Ad Hoc
2011 NIDDK Small Business Innovative Research Ad Hoc
2014 NHLBI Program Projects Ad Hoc
2014 NIDDK Kidney Stones- Special Emphasis Panel Ad Hoc
2015 Kidney Molecular Biology Genitourinary Organ Dev Ad Hoc
2020 Genitourinary Physiology Pathology Special Emphasis Panel Ad Hoc
2021-present Kidney Urologic Function and Dysfunction
Honors/Awards:
Donald W. Seldin Professor of Clinical Investigation (2002-present), Charles Pak Distinguished Chair in Mineral Metabolism (2003-present), Member, American Society of Clinical Investigation (2001-present), Member, American Association of Physicians (2007-present), Outstanding Freshman Teacher UTSouthwestern 2005, 2012, Notables of Physiology Teaching Award UT Southwestern 2013, Jack Coburn Award/Endowed Lectureship in Mineral Metabolism ASN 2015, Donald W. Seldin Endowed Lectureship in Renal Physiology (Inaugural) ASN 2018, Shaul Massry Award and Visiting Professorship. Shaul G. Massry Foundation 2020, Donald W. Seldin Award and Lectureship in Kidney and Cardiovascular Disease American Heart Association 2022
Board Certification: Internal Medicine, Nephrology
Research Interests: Kidney physiology and preclinical pathophysiology with direct relevance to human disease and aimed at translational applications. The physiologic areas of focus are acid-base-electrolytes and mineral metabolism and at the basic level, we concentrate on biochemistry, cell and molecular biology in epithelial transport and metabolism. We conduct research at all levels from human datamining to human metabolic studies, and to animal and cell models of pathophysiology. The clinical conditions driving our work, and being addressed are fluid and electrolyte disturbances, kidney stones, and cardiovascular and bone complications in acute kidney injury and chronic kidney disease.