Abstract: FR-PO535

Lactobacillus Plantarum 299v Prevents Clostridium difficile Infection in Patients Hospitalized in Nephrological and Transplantation Department

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 304 CKD: Epidemiology, Outcomes - Non-Cardiovascular

Authors

  • Adamczak, Marcin, Medical University of Silesia , Katowice, Poland
  • Dudzicz, Sylwia Malgorzata, Medical University of Silesia , Katowice, Poland
  • Kujawa-Szewieczek, Agata, Medical University of Silesia , Katowice, Poland
  • Kwiecien, Katarzyna, Medical University of Silesia , Katowice, Poland
  • Wiecek, Andrzej, Medical University of Silesia , Katowice, Poland
Background

Lactobacillus plantarum 299v (LP299v) has been introduced into the clinical practice in order to reduce gastrointestinal symptoms during antibiotic exposure. However, it remains controversial whether or not probiotics are also effective in the prevention of Clostridium difficile infections (CDI) among patients receiving antibiotics. The aim of this clinical, retrospective, single-centre study was to analyze the CDI among patients receiving antibiotics and hospitalized in the period before, during and after cessation of LP299v use, as a prevention of CDI, in the nephrological and transplantation department.

Methods

Among 5341 patients hospitalized in the nephrological and transplantation department during three years 40 patients with CDI were diagnosed and enrolled in this study. From November 2013 to December 2014 prevention of CDI with the oral use of LP299v was performed in all patients treated with antibiotics and after organ transplantation or receiving immunosuppressive drugs for any other reasons. For the further analysis the observation period was divided into three twelve-months periods: before, during LP299v use as the prophylactic manoeuvre against CDI and after cessation of such a prophylaxis

Results

A significant (p=0.0001) reduction of the number of cases with CDI was found during LP299v use (period 2) (n=2; 0.11% of 1791 hospitalized patients) compared two others periods i.e. before and after cessation of such a prophylaxis ( n=21; 1.21% of 1742 hospitalized patients and period and n=17; 0.94% of 1808 hospitalized patients, respectively).

Conclusion

Routine use of Lactobacillus plantarum 299v during treatment with antibiotics may prevent Clostridium difficile infection in the nephrological and transplantation department.

Funding

  • Government Support - Non-U.S.