Abstract: TH-PO751

Study of Vascular Intimal Thickness around Different Locations of Catheter Tips in Dog Model

Session Information

Category: Dialysis

  • 603 Hemodialysis: Vascular Access

Authors

  • Wang, Li Hua, nstitute of Urology & Key Laboratory of Tianjin, Tianjin, Tianjin, China
  • Jia, Lan, 2nd Hospital of Tianjin Medical University, Tianjin, China
  • Yu, Hai Bo, 2nd Hospital of Tianjin Medical University, Tianjin, China
  • Wei, Fang, 2nd Hospital of Tianjin Medical University, Tianjin, China
  • Jiang, Ai Li, 2nd Hospital of Tianjin Medical University, Tianjin, China
Background

Many studies have found intimal thickness around catheter tip after catheterization. Meanwhile Caveolin-1 is a shear sensor that may transmit mechanical change into biochemical signals resulting in vascualr remodeling.

Methods

TDCs were inserted into the left jugular vein and right femoral vein in eight dogs for 28 days. Histological and immunohistochemistry were performed to confirm specific cell populations after extracorporeal circulation.

Results

There were higher catheter dysfunction rates and low blood flow rates in the femoral vein group compared to left jugular vein group. There was intimal hyperplasia around the catheter tip in both group with no significant difference. There were also caveolin-1 expression between the different groups.

Conclusion

After catheter placement, focal areas of intimal thickening were seen in the venous wall adjacent to the catheter tip with a high expression of caveolin-1. These findings indicate that different catheter tip locations may influence catheter function and targeting of specific caveonlin-1 could be possible future novel therapies for haemodialysis vascular access stenosis.

Comparison of catheter function of study groups
ParameterLeft internal jugular vein catheter groupRight Femoral vein catheter groupP value
Blood flow(ml/min) 236±21197±130.001
Episode of catheter dysfunction1(12.5%)5(62.5%)0.035
Episode of catheter infection3(37.5%)4(50%)0.614