Abstract: SA-PO159

Association of Adiposity with Hemoglobin Levels in Patients with CKD Not on Dialysis

Session Information

Category: Nutrition, Inflammation, and Metabolism

  • 1401 Nutrition, Inflammation, Metabolism

Authors

  • Honda, Hirokazu, Showa University Koto Toyosu Hospital, Tokyo, Japan
  • Ono, Kota, Hokkaido University Hospital, Sapporo, Japan
  • Akizawa, Tadao, Showa University School of Medicine, Tokyo, Japan
  • Nitta, Kosaku, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan
  • Hishida, Akira, Yaizu City Hospital, Yaizu, Japan
Background

Adiposity influences erythropoiesis and iron metabolism in the general population. We therefore hypothesized that adiposity could be associated with erythropoiesis or impaired iron metabolism in patients with CKD; however, and that these associations would be influenced by the severity of CKD. The present study aimed to assess the relationship between adiposity—as estimated by body mass index (BMI) and abdominal circumference (AC)—and biomarkers of erythropoiesis in patients with chronic kidney disease (CKD) not on dialysis.

Methods

A total of 2,322 patients from the Chronic Kidney Disease Japan Cohort study were analyzed. Patients were grouped according to BMI category (low: BMI <18.5, normal: BMI 18.5-24.5, and high: BMI ≥25) and AC category (large: AC ≥90 cm for males and AC ≥80 cm for females, and; small: AC measurements below the large values<90 cm and <80 cm). Body composition and laboratory data were measured at baseline, 1 year, and 2 years.

Results

Multivariate regression analysis at 3 time points showed that a high BMI and large AC in male patients were significantly associated with higher hemoglobin levels. Hemoglobin levels in female patients with BMI<18.5 and small AC were lower than with 18.5≤BMI<25 and large AC, respectively (Fig. 1). However, hemoglobin levels were plateaued above threshold of 25 of BMI and 80cm of AC, respectively (Fig. 1). While BMI and AC were positively associated with C-reactive protein levels, they were not associated with levels of transferrin saturation, ferritin, and erythropoietin in multivariate models.

Conclusion

In conclusion, body composition may be associated with erythropoiesis;, however, adiposity may be only associated with increased erythropoiesis in male patients. It does not appear to hamper iron metabolism in CKD patients not on dialysis.

Funding

  • Commercial Support