Abstract: FR-PO556
Pregnancy Is Associated with Higher Central Systolic and Pulse Pressures in Later Life
Session Information
- Hypertension: Clinical and Translational
November 03, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Hypertension
- 1102 Hypertension: Basic and Experimental - Renal Causes and Consequences
Authors
- Pelletier, Karyne, Hopital du Sacre-Coeur de Montreal, Montreal, Alberta, Canada
- Cote, Anne-Marie, CHUS - Hopital Fleurimont, Sherbrooke, Quebec, Canada
- Madore, Francois, Hopital du Sacre-Coeur de Montreal, Montreal, Alberta, Canada
- Goupil, Remi, Hopital du Sacre-Coeur de Montreal, Montreal, Alberta, Canada
Background
Healthy pregnancy has been associated with increased arterial stiffness and central hemodynamics which normalises after delivery. Whether these changes portend to long-term changes in central blood pressures (BP) remains unknown.
Methods
Using the CARTaGENE populational database, central hemodynamic parameters were adjusted and compared between 1) women without previous pregnancies, 2) women with previous pregnancies of less than 20 weeks only and 3) women with previous pregnancies of longer term.
Results
Of 10,266 female CARTaGENE participants, 8,662 had previous pregnancies (666 with previous pregnancies ≤ 20 weeks only). Baseline characteristics are presented in the below table. After adjustment for important covariables, central systolic BP, central pulse pressure and augmentation index were higher in women with previous pregnancies ≤ 20 weeks than in women without pregnancies and with > 20 weeks pregnancies (p-values for trend <0.001, 0.001 and 0.04 respectively).
Conclusion
In this cohort, pregnancy was associated with increased central BP and indices of arterial stiffness in later life, the importance of which was greater when pregnancies longer than 20 weeks occurred. To what extent these differences could be explained by complications during pregnancy requires further investigations.
| Characteristics | No pregnancy (n=1,604) | Pregnancy ≤ 20 weeks or less only (n=666) | Pregnancy > 20 weeks (n=7,996) |
| Age | 54 ± 8 | 53 ± 7 a | 54 ± 8 b |
| Age of first pregnancy | - | 27 ± 7 | 25 ± 5 b |
| Diabetes | 7% | 7% | 7% |
| Cardiovascular disease | 4% | 4% | 4% |
| Treated hypertension | 19% | 15% a | 22% ab |
| Brachial systolic BP | 119 ± 15 | 118 ± 17 | 120 ± 16 ab |
| Brachial pulse pressure | 47 ± 11 | 47 ± 11 | 48 ± 11 ab |
| Heart rate | 70 ± 10 | 69 ± 11 | 69 ± 11 a |
| Adjusted central hemodynamic parameters | |||
| Central systolic BP | 113.2 (112.7, 113.7) | 113.5 (112.9, 114.1) | 114.1 (113.7, 114.6) ab |
| Central pulse pressure | 41.1 (40.3, 41.8) | 41.4 (40.6, 42.3) | 42.4 (41.8, 43.1) ab |
| Augmentation index | 31.2 (30.3, 32.0) | 31.7 (30.6, 32.7) | 31.8 (31.1, 32.6) a |
a p<0.05 vs no pregnancy; b p<0.05 vs pregnancy 20 weeks or less. Values are reported as mean ± standard deviation or as estimated marginal means (95%CI) adjusted for age, BMI, diabetes, cardiovascular disease, active smoking, total cholesterol, HDL-cholesterol, eGFR, uric acid, TSH, heart rate, mean BP and use of renin-angiotensin blockers, calcium channel blockers, diuretics, beta-blockers, statins and aspirin.