Kidney Week

Abstract: SA-PO148

The Effect of a Renal Specific Oral Nutritional Supplement on Nutritional Status in Non-Dialytic CKD

Session Information

• Nutrition, Inflammation, Metabolism: Clinical Trials, Biomarkers, Epidemiology
  November 04, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Nutrition, Inflammation, and Metabolism

• 1401 Nutrition, Inflammation, Metabolism

Authors

• Cheng, Wen-Yi, Abbott Laboratories Services Corp., Taipei, Taiwan

Wen-Yi Cheng,

• Hwang, Shang-Jyh, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Shang-Jyh Hwang,

• Lin, Chih-Ching, Taipei Veterans General Hospital, Taipei City, Taiwan

Chih-Ching Lin,

• Huang, Meng-Chuan, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Meng-Chuan Huang,

• Kelly, Owen J., Abbott Laboratories, Columbus, Alabama, United States

Owen J. Kelly,

Background

The purpose of this study was to determine if 1-2 servings/d of a renal specific ONS (oral nutrition supplement) aids in maintaining nutritional status and avoids potential deleterious consequences in non-dialyzed stage 3b-5 CKD patients due to low dietary protein intake.

Methods

This is a prospective, multicenter, single arm, and open label study. Non-dialyzed stage 3b-5 CKD patients, with or without type 2 diabetes mellitus, with serum albumin ≥ 3.0 g/dl, and currently receiving standard medical care but not scheduled for dialysis treatment within 18 months were recruited. Subjects were requested to consume 1-2 servings per day (475 kcal, 10.6 g protein per serving), renal specific ONS for 6 months based on individual needs under dietitian’s assessment. The change of serum albumin, body weight, and BMI were assessed for nutritional status. Protein and energy intakes were estimated from the dietary records. The outcomes on handgrip strength, blood biochemistries, appetite change, and quality of life were also examined.

Results

Totally 45 patients completed the intervention trial. Daily protein and energy intakes were elevated significantly 6 months later (+9.42 g/day, p<0.02; +175.37 kcal/day, p<0.001). Mean body weight and BMI increased significantly (+1.18 kg, p<0.001; +0.47 kg/m² p<0.001) but there was no significant difference in serum albumin (4.09 g/dl to 4.13 g/dl) after intervention for 6 months. However, handgrip strength and appetite improved significantly (+1.28 kg, p<0.001; +0.20 scores, p=0.03). There was no significant difference in the parameters of quality of life and the profiles of blood biochemistries.

Conclusion

The addition of renal specific ONS can maintain albumin level and improve anthropometry, handgrip strength, and appetite in non-dialyzed stage 3b-5 CKD patients compared to those who received standard diet counseling.

Funding

• Commercial Support –