Abstract: SA-PO446

Atrial Fibrillation and Risk of Decline in Cognitive Function in CKD

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 306 CKD: Cognitive Dysfunction, Depression, Quality of Life

Authors

  • Mccauley, Mark D., University of Illinois at Chicago, Chicago, Illinois, United States
  • Taliercio, Jonathan J., Glickman Urological and Kidney Institute, Cleveland, Ohio, United States
  • Rao, Panduranga S., University of Michigan Health System, Ann Arbor, Michigan, United States
  • Shafi, Tariq, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
  • He, Jiang, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States
  • Wang, Xue, UNIVERSITY OF PENNSYLVANIA, Philadelphia, Pennsylvania, United States
  • Yaffe, Kristine, UCSF, San Francisco, California, United States
  • Lash, James P., University of Illinois at Chicago, Chicago, Illinois, United States
  • Hsu, Jesse Yenchih, University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Ricardo, Ana C., University of Illinois at Chicago, Chicago, Illinois, United States
  • Darbar, Dawood, University of Illinois at Chicago, Chicago, USA, Chicago, Illinois, United States
  • Kansal, Mayank, University of Illinois at Chicago, Chicago, Illinois, United States
  • Go, Alan S., Kaiser Permanente Northern California, Oakland, California, United States
  • Kurella Tamura, Manjula, Stanford University, Palo Alto, California, United States
  • Feldman, Harold I., University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Kusek, John W., NIDDK, Bethesda, Maryland, United States
Background

Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, however this relationship has not been examined in persons with chronic kidney disease. We investigated the association between AF and changes in cognitive function over time in men and women enrolled in the Chronic Renal Insufficiency Cohort Study.

Methods

AF status was determined annually using 12-lead electrocardiogram and/or participant self-report. Global cognitive function was assessed biannually with the Modified Mini-Mental State Exam (3MS). Linear mixed effect regression was used to compare the association between time-updated AF status and longitudinal change in 3MS.

Results

Compared to individuals without AF (n= 3120) at baseline, individuals with AF (n=673) were older, had lower socioeconomic status, increased prevalence of cardiovascular disease, and lower estimated glomerular filtration rate. Baseline 3MS scores were similar (90.6 vs 91.3) in AF and non-AF groups. Median follow-up time was 5.8 years. Table below summarizes multivariable analyses.

Conclusion

Despite a greater burden of cardiovascular disease at baseline in individuals with AF, there was no independent association between AF and longitudinal changes in cognitive function.

Funding

  • NIDDK Support