Abstract: SA-PO117
Gut Microbiota in IgA Nephropathy: What Is the Possible Association with Clinical Manifestations?
Session Information
- Clinical Glomerular Disorders: Biomarkers and Molecular Profiling
November 04, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Glomerular
- 1005 Clinical Glomerular Disorders
Author
- Tang, Wen, Peking University Third Hospital, Beijing, China
Background
Few study have investigated the microbiota in IgA nephropathy (IgAN) and their association with clinical disease progression factors. In the present study, we investigated the microbiota in IgAN patients with relative normal renal function and further examed the association between clinical risk parameters of IgAN and microbial groups.
Methods
Fecal microbiota was studied in nineteen new diagnosed IgAN and fifteen matched healthy control. Microbiota composition and functional capacity were characterized using sequencing of the 16S rRNA gene on Illumina MiSeq platform Patients’ clinic parameters were also collected to investigate their association with the microbiota.
Results
The proportion of Bifidobacterium was higher but Bacteroidetes was lower in the patients with IgAN as compared to healthy control. Additionally, CCA (canonical correlation analysis) analyse （Figure 1） revealed that Bifidobacterium was positively associated with serum IgA level and 24 hour proteinuria. Lachnoclostridium was positively associated with present of hypertension. Bacteroides and Prevotella were negative with them. Escherichia-Shigella was positive with urinary red blood cell account.
Conclusion
This study has for the first time revealed the association between microbiota and the factors associated with IgAN progression, which found that Bifidobacterium was positive associated with disease progressive factors. Further research are need to understand the potential role of the Bifidobacterim in the IgAN
Figure 1 The correlations between bacterial community and hypertension（HBP）, urine red blood cell count (U_RBC_ul) , 24 hour urinary protein ( 24UTP) and serum IgA level (serum IgA)
Funding
- Government Support - Non-U.S.