Abstract: FR-PO187

Carotid Intima–Media Thickness Predicts Dialysis Vascular Access Failure in Hemodialysis Patients: A Prospective Study

Session Information

Category: Hypertension

  • 1103 Vascular Biology and Dysfunction

Author

  • Lee, Hong joo, Seoul Red Cross Hospital, Seoul, Korea (the Republic of)
Background

A well-functioning dialysis vascular access is a mainstay to perform an efficient hemodialysis. Dialysis vascular access dysfunction is a common cause of morbidity and mortality for the hemodialysis patients. Carotid intima–media thickness (cIMT) and carotid plaque are ultrasound imaging that measures carotid atherosclerosis and predicts potential stroke, myocardial infarction, and vascular death. Hence, we conducted our study to elucidate the predictive value of cIMT on dialysis vascular access failure from the patients with end-stage renal disease (ESRD) on hemodialysis.

Methods

All hemodialysis patients in Red Cross Hospital within a period of one year were included in the study. cIMT of the participants were measured at 6 points of the carotid artery including right and left common carotid artery, right and left bulb, and right and left internal carotid artery by using the carotid ultrasonography. Moreover, they were classified in 2 degrees of severity: more than 1.0 mm of maximal cIMT and less than 1.0mm of maximal cIMT. Dialysis vascular access dysfunction served as outcome variables over a median follow-up period of 12 months. Statistical analysis was carried out by using SPSS.

Results

Among the 58 cases, 19 of the patients and 29 events were having dialysis vascular access dysfunction for the 12 months follow-up period. The maximal cIMTs were 2.34±1.10. The patients with more than 1.0mm of maximal cIMT were older (66.08±11.92 versus 50.90±13.26) with lower protein and albumin and higher hemoglobin A1C than the patients with less than 1.0mm of maximal cIMT. However, maximal cIMT was not associated significantly with the level of lipid profiles, including total cholesterol, high and low density lipoprotein cholesterol, triglyceride, and phospholipid. We observed a positive correlation between weight, body mass index, triglyceride, and dialysis vascular access dysfunction. Dialysis vascular access dysfunction was significantly often occurred in the patients with more than 1mm of maximal cIMTs than the patients with less than 1mm of maximal cIMT.

Conclusion

Our results show that dialysis vascular access dysfunction may be associated with the maximal cIMT. Therefore, the measurement of cIMT may have an advantage for prediction of dialysis vascular access dysfunction in hemodialysis patients.