Abstract: SA-PO285

The Spectrum of Biopsy Proven Glomerular Disease among Children in China

Session Information

Category: Glomerular

  • 1005 Clinical Glomerular Disorders

Author

  • Nie, Sheng, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China
Background

Children with glomerular disease comprise an important part of pediatric patients worldwide, especially in developing countries. Nationwide epidemiological data on the spectrum of biopsy-proven glomerular diseases in children is currently limited in China.

Methods

We previously conducted a nationwide renal biopsy survey including 71,151 patients from 938 hospitals spanning 282 cities across China, over an 11-year period from January 2004 to December 2014. A total of 8547 pediatric patients (≤ 18 years old) were selected from the survey for current analysis. The demographic and clinical variables were extracted from referral records and pathological reports.

Results

We found nephrotic syndrome (49.5%) and proteinuria coexisted with hematuria (26.1%) were frequent indications of renal biopsy in children. Minimal change disease (MCD) was the most common primary glomerular disease (27.9%), followed by IgA nephropathy (IgAN) (17.0%) and mesangial proliferative glomerulonephritis (10.1%). Henoch-Schonlein purpura nephritis (13.2%) and lupus nephritis (LN) (8.8%) were two most common secondary glomerular diseases. Compare with male patients, female tended to be less frequently diagnosed as MCD (Odds Ratio [OR] 0.26, 95% CI 0.23-0.30) and Alport nephropathy (OR 0.38, 95% CI 0.21-0.69), while membraneous nephropathy (MN) (OR 2.91, 95% CI 2.41-3.51) and LN (OR 10.91, 95% CI 8.92-13.33) were more frequent in female patients, adjusting for age, region, indications of biopsy and hospital levels. Moreover, MCD (30.7%) was the most common glomerulopathy in adolescent (11-18 years old), while purpura nephritis (22.7%) was the major pathological diagnosis in younger children (0-10 years old). The frequency of MN and LN were varied greatly among different geographic regions of China.

Conclusion

In conclusion, we provided comprehensive information on the composition of pediatric glomerular diseases in China. The spectrum and clinicopathological correlations of pediatric glomerular diseases varied greatly across genders and age groups.

Funding

  • Government Support - Non-U.S.