Abstract: TH-PO953

Preeclampsia Predicts Chronic Dysfunction in Kidney Transplantation

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Soto-Vargas, Javier, Regional General Hospital 46, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico
  • Lemus, Karla Lucila, Regional General Hospital 46, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico
  • CHAVARRIA-AVILA, Efrain, UNIVERSIDAD DE GUADALAJARA, GUADALAJARA, Mexico
  • Parra, Renato, Regional General Hospital 46, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico
Background

The goal was to evaluate the renal and obstetric outcomes in pregnancy after kidney transplantation in a Mexican center

Methods

Kidney transplant recipients who underwent pregnancy after transplantation at Regional General Hospital of the IMSS between January 1997 and January 2016 were identified. Data on demographics, comorbidities and clinical and graft outcomes were collected with a median follow up of 61.3 months post-partum.

Results

There were 41 pregnancies identified in 34 recipients. The median age of recipient at childbearing was 26.5 years (IQR, 22.7-30.5) and the median interval from transplantation to conception was 84.4 months (IQR, 43-106). There was a difference between the median pre-pregnancy estimated glomerular filtration rate (eGFR) (91.0 mL/min/1.73 m(2); IQR, 71.0-106.0) and median eGFR at time of last post-partum follow up (66.0 mL/min/1.73 m(2); IQR, 37.0-87.5, P<0.001). 31 (75.6%) pregnancies ended in singleton live births. Pre-eclampsia occurred in 16 pregnancies (39.0%).
There were 7 (17.1%) patients with chronic dysfunction during the follow up, 4 (9.8%) lost their graft, and only one death was recorded, attributed to histoplasmosis. Only the occurrence of preeclampsia was associated with the development of chronic dysfunction and loss of graft (p=0.009 and p=0.018 respectively) independent of the presence of rejections.

Conclusion

Post-transplantation pregnancies with preeclampsia are associated with the development of chronic dysfunction and loss of graft.