Abstract: SA-PO863

Relationship between Abdominal Aortic Calcifications by a Plain Lateral Lumbar X-Ray and Coronary Artery Calcifications by a CT-Based X-ray in CKD Patients

Session Information

  • Vascular Calcification
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Mineral Disease

  • 1205 Vascular Calcification

Authors

  • Thanwirunroj, Kittisak, Bhumibol Adulyadej Hospital, Royal Thai Air Force, Bangkok, Thailand
  • Gojaseni, Pongsathorn, Bhumibol Adulyadej Hospital, Royal Thai Air Force, Bangkok, Thailand
  • Chittinandana, Anutra, Bhumibol Adulyadej Hospital, Royal Thai Air Force, Bangkok, Thailand
Background

The presence and severity of cardiovascular calcifications strongly predict cardiovascular mortality in patients with chronic kidney disease (CKD). Most studies examining calcifications in CKD patients use computed tomographic (CT)-based techniques which are relatively expensive to detect coronary artery calcifications (CAC). This study focuses on testing whether lateral abdominal radiographs, which are widely available and less costly, could be used instead of CT imaging.

Methods

A cross-sectional study was done in patients diagnosed as pre-dialysis CKD stage 3-5. All participants were detected CAC scores by a CT-based technique and abdominal aortic calcification (AAC) by a lateral plain film of the lumbosacral (LS) region within 3 months after enrollment. Medical data were collected from patients and medical records.

Results

A total of 70 patients (44 males, 26 females), aged 70.59 ± 10.16 years were enrolled in this study. There was a significant association between CT-based Agatston CAC scores and plain film-based AAC scores. The correlation coefficient (r) between CAC scores and 4-scale AAC, 8-scale AAC and 24-scale AAC were 0.399 (p = 0.001), 0.364 (p = 0.002) and 0.385 (p = 0.001), respectively. From ROC analysis, it was shown that AAC scores had strong correlation with CAC scores ≥ 400, which is considered to be a good predictor of cardiovascular mortality [figure 1].

Conclusion

Abdominal aortic calcification detected by lateral abdominal radiographs could be used instead of CT-based coronary calcification scores. Prognostic value of the abdominal aortic calcification in this population should be determined in large scale, prospective cohort studies.

Figure 1: ROC curve of various AAC scores to predict CAC scores ≥ 400 Agatston

Funding

  • Government Support - Non-U.S.