Abstract: TH-PO043

Circulating Levels of Tumor Necrosis Factor Alpha Correlate with Clinicopathological Features and Progression of IgA Nephropathy

Session Information

Category: Glomerular

  • 1001 Glomerular: Basic/Experimental Immunology and Inflammation

Authors

  • Li, Guanhong, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • Wu, Wei, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • Zhang, Xinyao, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • Wen, Yubing, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • Li, Xuemei, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  • Gao, Ruitong, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Background

Tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are considered to play an important role in IgA nephropathy (IgAN). However, it is still unknown whether circulating TNF-α or IL-6 is a prognostic marker of IgAN.

Methods

Circulating levels of TNF-α and IL-6 of 147 patients with IgAN and 20 healthy subjects were measured by chemiluminescence assay. Absolute renal risk (ARR) score was used to evaluate the dialysis/death risk. This study explored the relationship between the levels of serum TNF-α or IL-6 with clinicalopathological features and progression of IgAN.

Results

Circulating levels of TNF-α were higher in patients with IgAN than that in healthy controls (HC) (P=0.02). However, circulating levels of IL-6 in patients with IgAN did not differ from HC (P=0.54). Circulating levels of TNF-α, but not IL-6, were positively correlated with male (r=0.20, P=0.02), mean arterial pressure (r=0.26, P<0.01), 24 hour urine protein (r=0.22, P<0.01), urinary protein to serum creatinine ratio (r=0.26, P<0.01), serum creatinine (r=0.49, P<0.0001) and Cystatin C (r=0.51, P<0.0001) in IgAN. Circulating levels of TNF-α were negatively correlated with estimated glomerular filtration rate (r= -0.47, P<0.0001). According to Oxford classification, circulating levels of TNF-α were higher in patients with mesangial hypercellularity grade M1 than that in M0 (P=0.03). Circulating levels of TNF-α with tubular atrophy/interstitial fibrosis grade T2 were higher than that in T1 (P=0.02). Circulating levels of TNF-α in patients of Haas grade III∼V were higher than Haas grade I∼II (P<0.01). Circulating levels of TNF-α in patients of Lee grade III∼V were higher than Lee grade I∼II (P=0.02). Furthermore, circulating levels of TNF-α steadily increased with the ARR level (ARR=3 > ARR=2, P<0.001; ARR=2 > ARR=1, P=0.04).

Conclusion

Circulating levels of TNF-α, but not IL-6, detected by chemiluminescence immunoassay, were closely associated with main prognostic clinicopathological features and progression of IgAN.

Funding

  • Government Support - Non-U.S.