Abstract: FR-PO330

Novel Semi-Automated Kidney Volume Measurements in Autosomal Dominant Polycystic Kidney Disease

Session Information

Category: Genetic Diseases of the Kidney

  • 801 Cystic Kidney Diseases

Authors

  • Muto, Satoru, Juntendo University, Tokyo, Japan
  • Kawano, Haruna, Juntendo university, Tokyo, Japan
  • Horie, Shigeo, Juntendo University, Tokyo, Japan
Background

We assessed the effectiveness and convenience of a novel semi-automatic kidney volume (KV) measuring high-speed 3D-image analysis system SYNAPSE VINCENT® (Fuji Medical Systems, Tokyo, Japan) for autosomal dominant polycystic kidney disease (ADPKD) patients.

Methods

We developed a novel semi-automated KV measurement software for patients with ADPKD to be included in the imaging analysis software SYNAPSE VINCENT®. The software extracts renal regions using image recognition software and measures KV (VINCENT KV). The algorithm was designed to work with the manual designation of a long axis of a kidney including cysts. After using the software to assess the predictive accuracy of the VINCENT method, we performed an external validation study and compared accurate KV and ellipsoid KV based on geometric modeling by linear regression analysis and Bland-Altman analysis.

Results

One hundred twenty four patients (male 62, female 62) participated in this study. The median eGFR was 46.9 ml/min/1.73m2. Median accurate KV, Vincent KV and ellipsoid KV were 627.7 ml, 619.4 ml (IQR: 431.5–947.0) and 694.0 ml (IQR: 488.1–1107.4), respectively. Compared with ellipsoid KV (r = 0.9504), Vincent KV correlated strongly with accurate KV (r = 0.9968). Ellipsoid KV systematically under- or overestimate accurate KV, with a mean (± SD) percentage difference of 14.2% ± 22.0% (Figure 1a). Vincent KV did not systematically under- or overestimate accurate KV, with a mean (± SD) percentage difference of – 0.6% ± 6.0% (Figure 1b). There were no significant slice thickness-specific differences (p = 0.2980).

Conclusion

The VINCENT method is an accurate and convenient semi-automatic method to measure KV in patients with ADPKD compared with the conventional ellipsoid method.