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Abstract: SA-PO664

Concurrent Hemoperfusion and Hemodialysis in Patients with Acute Pesticide Intoxication

Session Information

Category: Dialysis

  • 602 Dialysis for AKI: Hemodialysis, CRRT, SLED, Others

Author

  • Gil, Hyo-Wook, Soonchunhyang university Cheonan Hospital, Cheonan, ChungcheongNam-do, Korea (the Republic of)
Background

Water soluble and insoluble chemicals in the pesticide formulation may be eliminated more effectively in time if hemodialysis (HD) and hemoperfusion (HP) are performed concurrently. This study is aimed at evaluating the efficacy of concurrent HP and HD in patients with acute pesticide intoxication.

Methods

Between January 2011 and December 2012, we used HP and HD consecutively (HP-HD group, 347 cases), and then during the next 2 years (January 2013 to December 2014), we used concurrent HP and HD (HPD group, 383 cases). We compared the clinical outcomes between the 2 groups. For HP, we used an Absroba 300C HP membrane and for HD, we used a Polyflux 170H HD dialyzer (Baxter).

Results

The mortality was higher in the HP-HD group than in the HPD group: (48.1 vs. 20.9%) for the overall mortality and (81.8 vs. 57.9%) for the paraquat (bipyridylium) mortality (p < 0.001). In multiple logistic analyses, age (p = 0.013), ingested volume (p < 0.001), and HP-HD (p = 0.014) were significant risk factors for mortality in the paraquat ingested group.

Conclusion

Concurrent HP and HD would be an effective and safe treatment for patients with acute pesticide intoxication, in particular, paraquat intoxication.

Funding

  • Government Support - Non-U.S.