Abstract: FR-PO499

Temporal Changes in the Pattern of Kidney Disease: Analysis Based on 40,759 Biopsy-Proven Cases in China From 2003 to 2014

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 304 CKD: Epidemiology, Outcomes - Non-Cardiovascular

Authors

  • Zhu, Huixian, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing China, Nanjing, China
  • Hou, Jin-Hua, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing China, Nanjing, China
  • Zhou, Minlin, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing China, Nanjing, China
  • Liang, Dandan, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing China, Nanjing, China
  • Shao, Si-Jia, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing China, Nanjing, China
  • Liu, Ye, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing China, Nanjing, China
  • Liu, Zhi-Hong, National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing China, Nanjing, China
Background

Global burden of disease showed that spectrum of disease in China has changed from infectious disease to non-infectious disease over the past 20 years and the latter has become one of the most leading public health problems. Epidemiologic studies reveal the temporal changes in the pattern of kidney disease, which might reliably inform future hypothesis driven studies and public health interventions.Thus, in this study we aimed to determine the temporal trends in kidney disease in 40,759 cases from 2003 to 2014.

Methods

We identified all patients with a native kidney biopsy specimen referred to the National Clinical Research Centre of Kidney Diseases in Jinling Hospital between 2003 and 2014. Temporal era was categorized into three consecutive 4-year time intervals (2003–2006, 2007–2010, and 2011–2014) and patients age was categorized into four intervals (14-24, 25-44, 45-59, and ≥60).

Results

In total, 40,759 cases with renal biopsy were analyzed. The mean age of the patients were 36.59±14.12 years old and 52.0% was male. Mean age of renal biopsy patients increased continuously and he proportion of patients over 60 years old mounted up from 5.6% to 9.9%. Primary glomerulonephritis (PGN), Secondary glomerulonephritis (SGN), Tubulointerstitial disease (TIN) and inherited kidney disease accounted for 67.1%, 26.4%, 2.9% and 2.5% respectively among cases of renal biopsy. IgA nephropathy (IgAN) (52.7%) was most common in PGN, immune-mediated disease accounted for 59.20% in SGN.The proportions of IgAN and focal segmental glomerulosclerosis (FSGS) had a downward tendency (P<0.001); while the proportion of membranous nephropathy (MN) increased significantly (P<0.001). Lupus nephritis and Henoch-Schonlein purpura nephritis this kind of immune-mediated diseases decreased significantly (P<0.001), diabetic nephropathy increased by nearly one time (P<0.001) from 2011 to 2014.

Conclusion

PGN remained the predominant kidney disease in China, of which, IgAN was the most common one. What was noteworthy was that the proportion of MN increased significantly, with a maximum increase in adolescent patients. The changing spectrum of kidney disease presented in this study provided a certain reference and basis for clinical diagnosis, prevention and epidemiological study.