Abstract: SA-PO030

Statins Can Offer Renal Protection in Patients with CKD or DM Afflicted with AKI

Session Information

Category: Acute Kidney Injury

  • 003 AKI: Clinical and Translational

Authors

  • Akhtar, Rabia, St Joseph Regional Medical Center/New York Medical College, Paterson, New Jersey, United States
  • Elshimy, Ghada, St Joseph Regional Medical Center/New York Medical College, Paterson, New Jersey, United States
  • Tabassum, Seme, St Joseph Regional Medical Center/New York Medical College, Paterson, New Jersey, United States
  • Chandran, Chandra B., St Joseph Regional Medical Center/New York Medical College, Paterson, New Jersey, United States
Background

Statins are some of the most commonly prescribed medications in the United States. Aside from the lipid-lowering effects, this class of medications may offer benefits to other organ systems and may play a role in preventing AKI through these pleiotropic effects. This has been studied most specifically in patients undergoing cardiac catheterization or cardiac surgery. Our study is unique in that it seeks to analyze whether the general population with CKD or diabetes not undergoing any cardiac surgery could also stand to benefit from statin therapy.

Methods

We conducted a chart review of 339 patients admitted to a major teaching hospital in New Jersey during the time period between 2000-2010 and had the diagnosis of AKI and then stratified patients as statin users and non-statin users. We aimed to study whether these groups had differences in their rates of recovery. A series of logistic regressions were conducted to investigate predictors of patients recovery. The predictors that were included in this analysis were race, HTN, DM, CKD, rhabdomyolysis, statin intensity, stage of CKD and mean HbA1c value.

Results

We found that in patients with normal kidney function, those who were on statins were not more likely to recover than patients not on statins (p > .05). However, among patients with chronic kidney disease, statins increased the odds that they would recover by a factor of 3.56 (p < .05). In addition, for patients with Diabetes Mellitus, statins increased the odds that a patient would recover by a factor of 3.81 (p < .05).

Conclusion

The results of our study show that statins may offer renal protection to patients with chronic kidney disease or diabetes and not just those undergoing cardiac catheterization or cardiac surgery. The results of our study also emphasize the need for further studies looking at statin use and outcomes in AKI. Further matched-analyses would be helpful to look at whether our results are reproducible.