Abstract: SA-PO062

AKI in Hospitalized Dermatology Patients: An Epidemiology Study in Two Chinese Centers

Session Information

Category: Acute Kidney Injury

  • 003 AKI: Clinical and Translational

Authors

  • Chen, Yuanhan, Guangdong General Hosiptial (Guangdong Academy of Medical Sciences), Guangzhou, China
  • Liang, Xinling, Guangdong general hospital (Guangdong Academy of Medical Sciences), Guangzhoou, China

Group or Team Name

  • China collaborative study on AKI
Background

Acute kidney injury (AKI) has become a worldwide public health problem, but little information is available in patients with skin diseases.

Methods

This study comes from the China collaborative study on AKI (ClinicalTrails.gov: NCT03054142; Ethical approval: GDREC.2016327H). The electronic medical information were collected retrospectively and the results of creatinine tests were analyzed by data mining. Total 4,710 hospitalized patients in the Department of Dermatology with at least two creatinine tests within 7 days were screened out from Sichuan Provincial People’s Hospital (n=3,978) and Guangdong General Hospital (n=732). AKI was defined and staged according to Kidney Disease Improving Global Outcomes criteria on the basis of changes in serum creatinine.

Results

Two-hundred and ninety-five (6.3%) patients were classified into AKI, including 121(41.0%) hospital-adquired and 174 (59.0%) community-adquired AKI. In the top 15 general skin diseases (more than 1% in hospitalized dermatology patients), the AKI incidences of psoriasis with systemic reaction (14.8%), erythroderma (12.8%), drug eruption (12.6%) and systemic lupus erythematosus (12.5%) were significant higher than the total incidence (Figure 1). In multivariate logistic regression model, these 4 skin diseases were associated with AKI after adjusted by chronic kidney disease and diabetes mellitus. The Odds ratio were 2.970, 1.932, 2.446 and 2.254, respectively. The mean lenth of hospital stay was 2 days longer and the median hospital cost was about $500 higher in patients with AKI than those without. In addition, the mortality was much higher in patients with AKI than those without (3.1% vs 0.1%, P < 0.001). After adjusted by age and comorbidities, the AKI was related to in-hospital death (Odds ratio 24.630).

Conclusion

AKI was common in the hospitalized dermatology patients. It is associated with significantly higher in-hospital mortality and resource utilization.

Figure 1. AKI incidence in the top 15 general skin diseases

Funding

  • Government Support - Non-U.S.