Kidney Week

Abstract: TH-PO732

Association of Anthropometric Obesity Measures with CKD in Chinese Individuals with Type 2 Diabetes

Session Information

• Diabetic and Obesity Induced Kidney Disease - Clinical - I
  November 02, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Diabetes

• 502 Diabetes Mellitus and Obesity: Clinical

Authors

• Cheng, Dongsheng, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China

Dongsheng Cheng,

• Wang, Niansong, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China

Niansong Wang,

Background

Obesity is associated with both type 2 diabetes and chronic kidney disease (CKD). It remains controversial whether anthropometric obesity measures are related to the risk of CKD in type 2 diabetic patients.

Methods

We investigated the association between anthropometric obesity measures including body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with chronic kidney disease in Chinese individuals with type 2 diabetes. CKD was defined as eGFR < 60ml/min/1.73m², the presence of albuminuria or both. Logistic regression was used to examine associations of obesity and CKD.

Results

A total of 4701 patients were included in the final analysis. The mean age was 55.7 years, and 59.7% was male. Of these patients, 1362 (29.0%) had CKD. Obesity (BMI≥28 kg/m²) was found in 18.2%, and overweight (BMI 24–28kg/m²) was 43.0%. The highest quartile of BMI (odds ratio [OR] 2.55 [95% CI 2.05-3.17]), WC (OR 1.86 [95% CI 1.50-2.30]) and WHR (OR 1.88 [95% CI 1.52-2.32]) was significantly associated with CKD compared with the lowest quartile after adjustment for multiple confounding factors. Interestingly, in the normal weight patients (BMI<24 kg/m²), no associations were found between quartiles of WC and CKD, whereas increased WHR were associated with CKD.

Conclusion

This study has highlighted a strong association between obesity and CKD in type 2 diabetes. In selected population, such as normal weight patients with type 2 diabetes, larger waist-to-hip ratio but not waist circumference is associated with CKD.