Kidney Week

Abstract: SA-PO769

Effect of Fluid Status on the Fat Mass Estimated by Bioimpedance in Hemodialysis Patients

Session Information

• Standard Hemodialysis for ESRD - I
  November 04, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Dialysis

• 601 Standard Hemodialysis for ESRD

Authors

• Abbas, Samer R., Renal Research Institute, New York, New York, United States

Samer R. Abbas,

• Thijssen, Stephan, Renal Research Institute, New York, New York, United States

Stephan Thijssen,

• Penne, Erik Lars, Medical Center Alkmaar, Alkmaar, Netherlands

Erik Lars Penne,

• Raimann, Jochen G., Renal Research Institute, New York, New York, United States

Jochen G. Raimann,

• Levin, Nathan W., None, New York, New York, United States

Nathan W. Levin,

• Kotanko, Peter, Renal Research Institute, New York, New York, United States

Peter Kotanko,

• Zhu, Fansan, Renal Research Institute, New York, New York, United States

Fansan Zhu,

Background

This prospective study utilizes calf bioimpedance spectroscopy (cBIS) to guide the attainment of dry weight (DW_cBIS) in chronic hemodialysis (HD) patients. In the present research we evaluate whether fat mass is altered when DW_cBIS is attained.

Methods

Target post-HD weight was gradually reduced from baseline (BL) until DW_cBIS was achieved. DW_cBIS was defined as the presence of both flattening of the curve of extracellular resistance during HD and the attainment calf normalized resistivity (CNR) in the normal range (Zhu, Physiol Mea 2008). Extracellular (ECV), intracellular (ICV) volume and total body water (TBW) were measured using whole body bioimpedance spectroscopy (Hydra 4200). Fluid overload (FO), lean body mass (LBM), and fat mass (FM) were calculated according to a body composition model (Chamney, Am J Clin Nutr 2007).

Results

Twenty-eight patients (13 females; 7 diabetic; age 53.7±12 years) achieved DW_cBIS over a period of 43.8±30.1 days. On average 16±10 measurements per patient were required to attain DW_cBIS. Although significant decreases in body weight, CNR and ECV pre and post HD were observed, LBM and FM at DWcBIS did not differ significantly from BL (Table 1). ECV/TBW and FO were non-significantly higher at BL compared to DW_cBIS (Table 1).

Conclusion

This study showed that attainment of DW_cBIS did not affect fat mass.

Table 1