Abstract: SA-PO883

Clinical Characteristics of Susceptible Factors and Nutritional Status in 576 Secondary Hyperparathyroidism Patients Undergoing Parathyroidectomy

Session Information

  • Mineral Disease: CKD-Bone
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Mineral Disease

  • 1203 Mineral Disease: CKD-Bone

Authors

  • Wang, Ningning, Department of Nephrology,The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
  • Jiang, Yao, Nanjing Medical University , Nanjing, China
  • Yang, Guang, Department of Nephrology,The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
  • Xing, Chang Ying, First Affiliated Hospital of Nanjing Medical University, Nanjing, JIangSu, China
  • Zha, Xiaoming, First Af?liated Hospital with Nanjing Medical University, Nanjing, China
Background

Secondary hyperparathyroidism(SHPT) is a common complication of chronic kidney disease-mineral and bone disorder(CKD-MBD). Parathyroidectomy(PTX) is the prior therapy for severe SHPT, however, few large samples studies on predisposing factors and nutritional status of severe SHPT were explored. We aim to analyze the characteristics of high risk group and summarize the nutritional status of CKD patients with PTX.

Methods

Clinical data of 576 PTX patients were collected and grouped according to the age and dialysis vintage.

Results

There were 55.9% males and the mean age of all PTX patients were (46.4±11.3) years. The major cause of CKD was chronic glomerulonephritis (91.5%). Severe SHPT was more common in middle aged patients with long hemodialysis vintage (Fig 1). Levels of serum intact parathyroid hormone(iPTH) were gradually reduced from young age group to old age group(Fig2). The levels of BMI were (21.9±3.5) kg/m2,which was negative correlated with serum iPTH levels. Serum albumin in each age group was lower than the reference range, and in age groups of ≤18 and >70 years old were lower than the other groups.

Conclusion

Susceptible factors of severe SHPT include middle age, chronic glomerulonephritis and long hemodialysis vintage. Focused surveillance and timely treatment for mild or moderate SHPT patients with risk factors are suggested.The elderly and juveniles severe SHPT patients may have more serious malnutrition and higher operation risk. We recommend personalized diagnosis and treatment strategy for CKD-MBD patients.

PTX patients were grouped according to the age and dialysis vintage.

Characteristics of blood bone metabolic indices in different age groups.

Funding

  • Government Support - Non-U.S.