Abstract: TH-PO992

Alteration in Body Mass Index and Estimated Glomerular Filtration Rate after Kidney Transplantation

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Tantisattamo, Ekamol, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan, United States
  • Vutthikraivit, Possawat, PHRAMONGKUTKLAO COLLEGE OF MEDICINE, BANGKOK, Thailand
Background

The pattern of post-transplant weight change and renal allograft function is unclear. We aim to determine this association.

Methods

A retrospective cohort study of 70 renal transplant recipients was divided into 3 groups (BMI <25, 25 to <30, and ≥30 kg/m2). Changes in the mean BMI compared to pre-transplant BMI (ΔBMI) every 3-month follow-up periods up to 96 weeks post-transplant were correlated with post-transplant eGFR and changes in mean eGFR (ΔeGFR) during the corresponding 3-month follow-up.

Results

Compared to pre-transplant BMI, BMI at the time of discharge from the transplant admission increased in 3 groups (p=0.003, 0.000, and 0.514). In normal and overweight groups, BMI was lower during the first 4- and 12-week post-transplant compared to BMI at the time of transplant, respectively (p=0.236 and p=0.012-0.069) and then became persistently higher through 96 weeks post-transplant (p=0.001-0.122 and p=0.004-0.299). Mean eGFR continued trending up post-transplant until 24-week post-transplant and appeared to be plateau among all 3 BMI groups (Figure). By comparing mean eGFR every 12-week interval during post-transplant, there was no difference among 3 groups. In addition, ΔBMI between consecutive 3-month follow-up period did not associate with ΔeGFR at the corresponding 3-month follow-up period (p=0.104-0.922). The probability of developing worsening CKD stage was higher in overweight and obese groups compared to normal weight group, but there was no statistical significance (HR 0.697 (CI 0.296 to 1.641) for overweight and HR 0.695 (CI 0.279-1.728) for obese compared to normal weight group - Figure).

Conclusion

eGFR appears to increase with weight loss during the first 24-month post-transplantation in all BMI strata; however, it does not significantly change and not associated with BMI alteration thereafter. Pre-transplant obesity may not be the main determinant for post-transplant renal allograft function during early and late post-transplant periods.