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Kidney Week

Abstract: SA-PO677

Quality of Life in Caregivers Compared with Dialysis Recipients: The CO-ACTIVE Substudy of the ACTIVE Dialysis Trial

Session Information

Category: Dialysis

  • 604 Home and Frequent Dialysis


  • Gray, Nicholas A., Sunshine Coast University Hospital, Birtinya, New South Wales, Australia
  • Hong, Daqing, Sichuan Provincial People's Hospital, CHENGDU, China
  • Smyth, Brendan, None, Newtown, New South Wales, Australia
  • Jun, Min, The George Institute for Global Health, UNSW Sydney, Newtown, New South Wales, Australia
  • Howard, Kirsten, University of Sydney , Sydney, New South Wales, Australia
  • Rogers, Kris, The George Institute for Global Health, Sydney, New South Wales, Australia
  • Perkovic, Vlado, The George Institute for Global Health, Sydney, New South Wales, Australia
  • Zuo, Li, Peking University People's Hospital, Beijing, China
  • Jardine, Meg J., The George Institute for Global Health, UNSW, Newtown, New South Wales, Australia

Group or Team Name

  • ACTIVE Dialysis Steering Committee

The support of people living with chronic illness may be dependent on voluntary caregivers whose well-being is critical for patient management.


A subgroup of participants in the ACTIVE Dialysis study and their nominated caregivers completed quality of life (QOL) questionnaires including the EQ5D, SF-36 physical composite score (PCS) and mental composite score (MCS) as well as the Personal Wellbeing Index. Data was collected at baseline (prior randomisation to standard or extended hour dialysis) and every quarter until study end at 12 months. Baseline caregiver QOL was compared with dialysis patient QOL using paired t test for continuous variables, while predictors of baseline caregiver QOL were determined using multivariable regression.


There were 54 patient and caregiver pairs, predominantly from China. Caregivers had a mean (SD) age of 53.4 (11.3) years and 56% were female. Most (89%) were married or lived with a partner and 24% were in paid employment. Half were educated to secondary school and 33% to university level. Caregivers mostly cared for their spouse/partner (67%) or child (11%), while 20% reported admission to hospital in the preceding year. At baseline, caregivers had a better physical but similar mental QOL compared with dialysis patients (PCS: 46.9±8.7 vs 40.4±10.2, P<0.001); MCS: 47.8±9.7 vs 49.6±12.0, P=0.84). Chinese SF-36 population norms are 77.5 for PCS and 73.6 for MCS. EQ5D for caregivers was 0.9 (0.2) compared with 0.8 (0.2) for dialysis patients (P=0.054). The Chinese EQ5D norm is 0.92. Personal Wellbeing Index was 43.7±15.5 for caregivers (Chinese norm 60-70). Higher SF-36 scores among caregivers was predicted by university education but not age, gender or daily hours spent caring.


Caregivers have a higher physical QOL and equivalent mental QOL to dialysis patients but poorer physical QOL, mental QOL and personal wellbeing than the general Chinese population. University education predicts better QOL and may be a surrogate for current financial resources or other socioeconomic factors.(NCT00649298)


  • Private Foundation Support