Kidney Week

Abstract: FR-PO422

Indian Chronic Kidney Disease (ICKD) Study: A Prospective Cohort Study of CKD Patients in India

Session Information

• CKD: Risk Factors for Incidence and Progression - I
  November 03, 2017 | Location: Hall H, Morial Convention Center
  Abstract Time: 10:00 AM - 10:00 AM

Category: Chronic Kidney Disease (Non-Dialysis)

• 301 CKD: Risk Factors for Incidence and Progression

Authors

• Yadav, Ashok Kumar, PGIMER, Chandigarh, India

Ashok Kumar Yadav,

• Kumar, Vivek, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Vivek Kumar,

• Bhansali, Shobhit, PGIMER, Chandigarh, India

Shobhit Bhansali,

• Modi, Gopesh K., Samarpan kidney Institute & Research Ctr., Bhopal, MadhyaPradesh, India

Gopesh K. Modi,

• Gang, Sishir D., MULJIBHAI PATEL UROLOGICAL HOSPITAL, Nadiad, Gujarat, India

Sishir D. Gang,

• Prakash, Jai, Banaras Hindu University, Varanasi, India

Jai Prakash,

• Sircar, Dipankar, IPGMER,SSKM HOSPITAL, KOLKATA, India

Dipankar Sircar,

• Parameswaran, Sreejith, JIPMER, Ponidcherry, India

Sreejith Parameswaran,

• Prasad, Narayan, SGPGIMS CAMPUS, Lucknow, India

Narayan Prasad,

• SAHAY, MANISHA, OSMANIA HOSPITAL, HYDERABAD, India

MANISHA SAHAY,

• Varughese, Santosh, CMC, Vellore, India

Santosh Varughese,

• Singh, Shivendra, Banaras Hindu University, Varanasi, India

Shivendra Singh,

• Jha, Vivekanand, George Institute for Global Health, New Delhi, India

Vivekanand Jha,

Background

The Indian Chronic Kidney Disease (ICKD) study (https://ickd.georgeinstitute.org.in/) is a multi-centric, prospective, observational cohort study of early stage CKD patients in India which will ascertain rate and factors influencing progression of CKD in India.

Methods

Adult subjects with mild to moderate CKD [estimated glomerular filtration rate (eGFR) 30-60 ml/min/1.73m² or eGFR >60 ml/min/1.73m² with proteinuria/albuminuria] are eligible for enrolment. Approximately 5000 subjects would be enrolled over 18 months. Time to 50% decline in eGFR, need of renal replacement therapy, CVD event or death are primary end points. A central bio-repository with serial biological samples is coupled with this cohort. Socio-economic aspects of treatment will also be studied.

Results

A total of 1567 subjects have been enrolled in the ICKD cohort till May 2017. The cause of CKD could not be ascertained in 25% of subjects. Chronic glomerulonephritis, diabetic kidney disease and chronic interstitial nephritis are causes for CKD in 16.5%, 18% and 17% of subjects, respectively. Tables 1 shows selective demographic characteristics of enrolled subjects. Majority are males belonging to rural areas with occupation exposure to sand, dust, chemicals or animals etc. 24% subjects had used alternative drugs and 10% had history suggestive of AKI in the past.

Conclusion

This is the first and most comprehensive description of an early stage CKD cohort from a developing country.

Funding

• Government Support - Non-U.S.