Abstract: TH-PO935

The Change in Carotid Arterial Inflammation in De Novo Renal Transplant Recipients as Assessed by 18F-FDG PET/CT

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Yoon, Hye Eun, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea (the Republic of)
  • Kim, Yaeni, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea (the Republic of)
  • Yang, Chul Woo, Seoul St. Mary's Hospital, Seoul, Korea (the Republic of)
  • Kim, Yong-Soo, Seoul St. Mary's Hospital, Seoul, Korea (the Republic of)
  • Shin, Seok Joon, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea (the Republic of)
Background

Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease, and characterized by increased inflammation. Inflammatory activity of the arterial wall can be assessed by measuring 18F-fluorodeoxyglucose (18F-FDG) uptake with positron emission tomography computed tomography (PET/CT). Data on change in arterial inflammation in CKD patients after renal transplantation are not available to date. This study investigated the change in the inflammatory activity in carotid artery after renal transplantation in CKD patients.

Methods

We assessed 18F-FDG uptake, quantified as target-to-background ratio (TBR), in the right and left carotid arterial walls in 10 CKD patients. 18F-FDG PET/CT was performed before transplantation and at post-transplantation 4 months. TBR was evaluated in the whole carotid artery (WH) and most diseased segment (MDS). Most diseased segment (MDS) was defined as the 1.5-cm arterial segment, centered on the slice of artery demonstrating the highest 18F-FDG uptake at baseline. WH-TBRmax was calculated as the mean of maximum TBR values for all of the whole carotid artery segments, and WH-TBRmean was calculated as the mean of averaged TBR values of the whole carotid artery segments. MDS-TBRmax was calculated as the mean of maximum TBR values derived from 3 contiguous axial segments of the MDS, and MDS-TBRmean was calculated as the mean of averaged TBR values of the MDS segment.

Results

Eight patients showed a reduction in right Whole-TBRmax and WH-TBRmean, and left MDS-TBRmean, WH-TBRmax, and WH-TBRmean. Seven patients showed a reduction in right MDS-TBRmax and MDS-TBRmean, and left MDS-TBRmax. There was a tendency of reduction in right WH-TBRmax MDS-TBRmax, and MDS-TBRmean (% reduction [95% CI]: -6.50% [-12.81, 1.54]; -4.06% [-13.42, 9.38]; -4.47% [-13.64, 7.29]) and in left WH-TBRmax, WH-TBRmean, MDS-TBRmax, and MDS-TBRmean, (% reduction [95% CI]: -6.13% [-15.17, 8.32]; -8.37% [-17.62, 6.56]; -6.14% [-14.53, 7.01]; -7.29% [-17.91, 4.18]). The right Whole-TBRmean was significantly reduced from baseline (% reduction [95% CI]: -5.74% [-15.37, -0.02], P = 0.047).

Conclusion

The 18F-FDG uptake of WH and MDS were reduced after renal transplantation. Renal transplantation may confer an anti-inflammatory effect on carotid atherosclerosis in CKD patients.

Funding

  • Government Support - Non-U.S.