Abstract: SA-PO747

Enhanced Phosphate Clearance of Dialyzers by Membrane Inner Surface Structure Optimization

Session Information

Category: Dialysis

  • 601 Standard Hemodialysis for ESRD

Authors

  • Xu, Tiancheng, Wego Blood Purification Products Co.,Ltd., Weihai, China
  • Zhang, Chunyao, Wego Blood Purification Products Co.,Ltd., Weihai, China
  • Wang, Xingya, Wego Blood Purification Products Co.,Ltd., Weihai, China
  • Mu, Changjun, WEGO blood purification products Co.,Ltd, Weihai, China
Background

Elevated phosphate levels increased morbidity and mortality among dialysis patients, so the control of serum phosphate concentration is a considerable clinical approach. To enhance the phosphate clearance of dialyzers, hemodialysis membranes with different properties of inner surface structure have been specially developed and researched.

Methods

Firstly, SEM, dextran retention method (DRM),SurPASS and liquid-liquid displacement porometry (LLDP) were used to characterize the zeta potential, mean flow pore diameter of membranes respectively in MF13 and F6HPS dialyzers. In addition, a case-control study including 105 chronic kidney diseases patients (55 males, 50 females, mean age 56 years) enrolled at two hospitals in China who had been undergone stable hemodialysis for at least three months was conducted in 2016. Polysulphone dialyzers (Fresenius F6HPS or Wego MF13) were applied to each hemodialysis treatment. Finally, the SPSS PASW (statistical package of social science) Statistics v18.0 (SPSS Inc., Chicago, IL, USA) was used to analyze the patient data.

Results

When pH=7.0 (close to the blood pH of the hemodialysis patient), the membrane inner surface zeta potential of MF13 (-17.1 mv) was slightly lower than F6HPS (-15.0 mv), but the mean flow pore diameter of membrane of MF13 (28.3 nm) was much larger than F6HPS (22.2 nm). A thinner inner surface and higher inner surface porosity were obtained in the membrane of MF13. According to the tortuous capillary pore diffusion model, the increase of kM followed by the rp has been concluded, which leads the prediction of the removal of phosphate in MF13 being superior to F6HPS theoretically. In fact, the clinical datas with significant differences between MF13 and F6HPS for total 105 HD patients being randomly divided into two groups were presented in Table 1.

Conclusion

The mean flow pore diameter, surface thickness and porosity are the determinant factors of phosphate clearance when the other characteristics of membrane inner surface structure were same, such as membrane surface materials and surface zeta potential.

OutcomePhosphorus clearancePhosphorus decrease
F6HPSMF13F6HPSMF13
N53525352
Mean152.2170.352.357.6
SD34.625.412.411.6
MSD4.83.51.71.6
PP=0.003<0.05P=0.025<0.05

Funding

  • Other NIH Support