Abstract: TH-PO165
Improvement of Clinical Outcome in Kidney Diseases via the On-line Thai Glomerular Disease Registry: Minimal Change Disease
Session Information
- Clinical Glomerular Disorders: FSGS, MN, MCD
November 02, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Glomerular
- 1005 Clinical Glomerular Disorders
Authors
- Pattharanitima, Pattharawin, Thammasat University, Pathumthani, Thailand
- Chawanasuntorapoj, Ratana, Siriraj Hospital, Bangkok, Thailand
- Pichaiwong, Warangkana, RAJAVITHI HOSPITAL, Bangkok, Thailand
- Sangthawan, Pornpen, Prince of Songkla University Hospital, Songkhla, Thailand
- Tantranont, Ngoentra, Siriraj Hospital, Mahidol University, Bangkok, Thailand
- Cheunsuchon, Boonyarit, Siriraj hospital, Bangkok, Thailand
Group or Team Name
- Thai Glomerular Disease Collaborative Network (TGCN)
Background
The data on prevalence, clinical characteristics and outcomes of minimal change disease (MCD) in Thailand is sparse. The available data came from few medical schools which might not represent the entire Thai population. The Thai Glomerular Disease Collaborative Network (TGCN) was established to determine the prevalence, clinical characteristics, outcomes and prognosis in Thai glomerular disease patients.
Methods
The data collected prospectively from TGCN included adult patients with biopsy-proven glomerular disease from institutes in Thailand participating in TGCN from July 2014 to March 2017. The clinical and renal pathology characteristics, treatment regimens at the time of renal biopsy, clinical outcomes, and complications at 24, 48 and every 48 weeks after renal biopsy were obtained via online data collection forms.
Results
Among 1,556 patients, 115 (7.4%) had MCD. At baseline, 53% of MCD patients were male, the mean age was 46.5 + 17.2 years, median serum creatinine (sCr) was 1.02 mg/dL (0.5-10.7), mean urine protein creatinine ratio (UPCR) was 5.99±4.72 g/g.Cr, mean serum albumin (sAlb) was 2.4±0.9 g/dL, and mean serum cholesterol (sChol) was 422±194 mg/dL. At 24 weeks, 62% had complete remission, and 19% had partial remission. Median time to remission was 1.5 months. The odd ratio of remission was 3.13 in patients with UPCR >5 (P=0.047). The age, sAlb, sChol, sCr at time of biopsy and pathological characteristics were not different between remission and non-remission groups. The 1.5% of them had doubling serum creatinine, none of them developed ESRD and 1.4% of patient died during the study.
Conclusion
Conclusions: The outcome of the adults with MCD was excellent. The patients with UPCR >5 at baseline had more favorable outcome.
Funding: Health Systems Research Institute and Nephrology Society of Thailand support
Funding
- Private Foundation Support