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Abstract: FR-PO183

CD4 Lymphopenia Is Associated with Cardiovascular Disease in Patients with Non-Dialysis Dependent CKD

Session Information

Category: Hypertension

  • 1103 Vascular Biology and Dysfunction

Authors

  • Iio, Kenichiro, National Hospital Organization, Osaka Minami Medical Center, Kawachinagano, Japan
  • Ando, Yutaka, National Hospital Organization, Osaka Minami Medical Center, Kawachinagano, Japan
Background

The role of T cells in the pathogenesis of atherosclerosis is complex. T-cell infiltration is thought to occur at atherosclerotic sites; CD4 lymphopenia in HIV patients is associated with atherosclerosis. Patients with chronic kidney disease (CKD) not only have a high prevalence of cardiovascular disease (CVD), but their circulating CD4 lymphocyte count is also decreased. The aim of this study was to assess the relationship between CVD and circulating T cell phenotype in patients with CKD.

Methods

We enrolled 97 patients with CKD stages 3-5 (mean age 68.4 ± 12.1 years; 65 males [67%]; CKD stage 3/4/5, 32/14/51) who were hospitalized between June 2013 and May 2017. We determined the numbers of immune cell phenotypes (CD4+, CD8+, CD28+CD8+) and the ratio of CD4/CD8 cells in peripheral blood or peripheral blood mononuclear cells using flow cytometry, to define their relationships with CVD, prospectively.

Results

Among 28 (29%) CVD patients, CD4+ (678 vs. 473, p = 0.004) and CD28+CD8+ (147 vs. 97, p = 0.012) cell counts were significantly lower and this group was significantly older (age 67 vs. 72 y, p = 0.09) than non-CVD patients. Multivariate logistic analysis indicated a significant negative association between CVD and the number of CD4+ T cells (odds ratio, 0.997; 95% confidence interval, 0.995 - 1.000, p=0.023).

Conclusion

Peripheral blood CD4 lymphopenia is associated with CVD in patients with non-dialysis CKD. CD4 lymphopenia may reflect atherosclerosis in CKD patients.