Abstract: FR-PO847

Association of Betaine with Blood Pressure in Dialysis Patients

Session Information

Category: Dialysis

  • 606 Dialysis: Epidemiology, Outcomes, Clinical Trials - Cardiovascular

Authors

  • Wang, Lulu, Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
  • Zhao, Mingming, Peking University, Beijing, China
  • Liu, Wenjin, 2nd Affiliated Hospital of Nanjing Medical University, Nanjing, China
  • Zheng, Lemin, Peking University, Beijing, China
  • Yang, Junwei, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
Background

Patients with chronic kidney disease have an increased risk of cardiovascular morbidity and mortality. Hypertension has been considered as one of the most important contributor to the increased risk. Betaine is a zwitterionic quaternary ammonium compound and distributed widely in rich dietary sources. Previous studies suggest a possible link between alteration of circulating betaine and hypertension. However, there is a paucity of data regarding patients on maintenance hemodialysis. We aimed to explore the association of betaine with blood pressure in this disease population.

Methods

Between July 2015 to July 2016, 368 patients on maintenance hemodialysis (4h / thrice weekly over 3 months) from six tertiary hospitals were recruited to participate an ongoing cohort study. Interdialytic blood pressure was evaluated by ambulatory blood pressure monitoring. Plasma betaine level was measured by high performance liquid chromatography–mass spectrometry for 327 subjects. The association between betaine and blood pressure was evaluated by multiple linear regression analysis.

Results

The mean age of the patients was 52.6±11.9 years, and 58.4% were male. Average interdialytic ambulatory systolic and diastolic blood pressure were 138.4±22.7 mm Hg and 84.4±12.5 mm Hg, respectively. Mean plasma betaine level was 37.6 umol/L. There was no significant difference of plasma betaine level across certain subgroups, including age (>60 vs. ≤60), gender (male vs. female), BMI (≥25 vs. <25),diabetes (yes vs no) and previous history of cardiovascular disease (yes vs no). Multiple linear regression analysis revealed significant associations of betaine with both systolic blood pressure (β=-3.66,P=0.003) and diastolic blood pressure (β=-2,P=0.004). The associations persisted even after extensive adjustment for cardiovascular covariates.

Conclusion

In conclusion, we demonstrated, for the first time, significant association between betaine and blood pressure level in a group of hemodialysis patients. Our data suggests that alteration of circulating betaine possibly contributes to blood pressure regulation in these patients.

Funding

  • Government Support - Non-U.S.