Abstract: SA-PO907

Kidney Stones Associate with Increased Risk for Fracture in Patients with CKD

Session Information

  • Mineral Disease: CKD-Bone
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Mineral Disease

  • 1203 Mineral Disease: CKD-Bone

Authors

  • Shin, Dong Ho, College of Medicine, Hallym University, Seoul, Korea (the Republic of)
  • Noh, Jung-woo, Hallym University, Seoul, Korea (the Republic of)
  • Lee, Jeonghwan, Hallym University Hangang Sacred Heart Hospital, Seoul, Korea (the Republic of)
Background

Most of kidney stones may result from renal hypercalciuria, which is a systemic dysregulation of calcium homeostasis. Accordingly, fractures related with this dysregulation occur more frequently in patients with nephrolithiasis than in the general population. However, little is known about the potential influence of kidney stones on bone health status in patients with chronic kidney disease (CKD).

Methods

A total of 2284 patients with stage 3 – 4 CKD, who were treated at Kandong Scared Heart Hospital were included. Patients were divided into 2 groups according to the presence and absence of kidney stones, and clinical and laboratory data were compared between groups. The association of fractures with kidney stones analyzed using Cox proportional hazards analysis.

Results

Patients with kidney stones and without kidney stones were 502 and 1782, respectively. Among these patients, 172 (7.4 %) were diagnosed with fractures. Hip, pelvis, vertebra, proximal humerus or distal forearm fractures were 43, 31, 50, and 48, respectively. Compared to patients without kidney stone, patients with kidney stones had a significantly higher proportion of fractures (12.4 % vs 6.2 %, P = 0.02). In particular, Cox proportional hazard analysis revealed that kidney stones were a significant independent predictor of vertebral fracture even after adjusting for other factors in patient with CKD stage 3-4 (HR, 1.81, 95% CI 1.12 – 1.81, P = 0.04).

Conclusion

Kidney stones are at increased risk for fractures. Especially, kidney stones are independently associated with higher risk of vertebral fracture in patients with CKD.