Abstract: TH-PO861

APD Could Alleviate Acute Left-Heart Failure via Increasing Peritoneal Dialysis Ultra-Filtration: A Single Center Observation Clinical Research

Session Information

  • Peritoneal Dialysis - I
    November 02, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Dialysis

  • 608 Peritoneal Dialysis

Author

  • Ai, Jun, Nanfang Hospital, Southern Medical University, Guangzhou, China
Background

Ultrafiltration failure (UFF) is a major reason which causing water retension, acute left-heart failure (LHF), and peritoneal dialysis (PD) failure for PD patients. Automated peritoneal dialysis (APD) might have better ultra-filtration than CAPD. We had observed whether short time APD could increase UF and alleviate LHF.

Methods

Patients had been collected since December 1, 2015 to Jan 1, 2017 in Renal Department, Nanfang Hosipital of Southern Medical University. All patients had been treated with CAPD (mean dialysate glucose concentration 2.0±0.3%, total dialysate volume 8.3±1.1L) before came to our center and were treated with APD in the hosipital (mean dialysate glucose concentration 2.0±0.2%, 4 cycles per night, total treatment volume 9.6±1.2L, total treatment time 12.0±2.0h) . Fluid state, peritoneal ultra-filtration volume, 24h urine volume, body weight, blood pressure were collected and compared between the last three days before receiving short-time APD and in those when receiving short-time APD. Serum creatinine, BUN, albumin, potassium, hemoglobin and glucose were collected and compared before and after receiving APD, respectively. Manifestation and grades of left heart failure were collected and comparted before and 3 days after receiving APD.

Results

A total of 47 patients (31 men, mean age 46.8±16.2yr) were enrolled in this study. The mean duration of CAPD was 26 months (2-195months). Of the 47 patients, peritoneal dialysis UF was significantly increased when receiving short-time APD than that of CAPD (1261.9±329.6ml vs 706.2±222.3ml, p<0.001), and body wights had significantly decreased 3 days after treated with APD (57.73±10.5 Vs 59.81±10.8, p<0.001). The grades of LHF were significantly decreased 3 days after receiving APD (1.7±0.8 vs 2.4±1.0, p<0.001), also manifestation of LHF had been significant improved 3 days after receiving APD ( 40% vs 70%, p= 0.007). Blood pressre were well controled 3 days after treated with APD (146.6±14.4 vs 162.5±23.8 of SBP, p= 0.0007, and 85.6±11.1 vs 95.6±14.7 of DBP, p=0.001). There were no changed in serum creatinine, albumin, potassium, nor hemoglobin.

Conclusion

In conclusion, short-time APD could significantly increase ultrafiltration, alleviate edema and acute left heart failure, which might be an effective method to treat UFF and acute left heart failure in PD patients.