Abstract: TH-PO969

Dynamic Contrast Computed Tomography as a Separate Renal Function Test for Living Renal Transplantation Donors

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Hasegawa, Midori, Fujita Health University School of Medicine , Toyoake, Japan
  • Iwasaki, Jin, Fujita Health University School of Medicine , Toyoake, Japan
  • Takahashi, Kazuo, Fujita Health University School of Medicine , Toyoake, Japan
  • Hayashi, Hiroki, Fujita Health University School of Medicine , Toyoake, Japan
  • Koide, Shigehisa, Fujita Health University School of Medicine , Toyoake, Japan
  • Inaguma, Daijo, Fujita Health University School of Medicine , Toyoake, Japan
  • Yuzawa, Yukio, Fujita Health University School of Medicine , Toyoake, Japan
Background

Non-ionic contrast agent is stable in vivo and is eliminated without being metabolized, exclusively by glomerular filtration. The purpose of this study is to establish the method of measurement of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) by dynamic computed tomography (CT), for use in accurate separate renal function evaluation.

Methods

When preoperative abdominal contrast-enhanced CT of renal transplant donor candidates was performed, low level radiation (8 mSv) dynamic CT images were added every 2 for 30 seconds. The region of interest (ROI) was set at the right and left renal artery just before branching, and the CT value in the ROI was obtained. A time-density curve was derived from the CT value and photographing time. ERPF was calculated using the Patlak plot method. GFR was calculated using a 3-compartment model (intra-arterial, extracellular space, glomerulus) analytic method. CT based GFR was compared with inulin clearance results.

Results

Table 1 shows the results in 5 renal transplant donors. CT-based GFR closely coincided with inulin clearance. The filtration fraction (GFR/ERPF) was 0.22±0.03. Figure 1 shows the images of ERPF and GFR.

Conclusion

This method can be clinically applied for separate renal function evaluation.

Table 1. The results of 5 renal transplant donors

Figure1 The images of ERPF and GFR