Abstract: FR-PO986

Computational Volume-Analysis of Compensatory Hypertrophy of the Kidney after Contralateral Nephrectomy

Session Information

Category: Bioengineering and Informatics

  • 101 Bioengineering and Informatics

Author

  • Nagayma, Jun, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
Background

Kidney volume usually increases after contralateral nephrectomy according to the preoperative disease-affected kidney function. We preliminarily assessed post-nephrectomy-parenchymal volume divided into two regions (cortex and medulla) to examine compensatory hypertrophy in each using computational volume analyzer on new computational imaging technologies.

Methods

The arterial-phased enhanced imaging data (DICOM formatted) of 11 patients (age ranged between 51 and 86) were obtained from the institutional database. Nephrectomy was underwent in all patients in which 7 renal cell carcinoma , 3 pelvic and ureteral cancer and 1 pyonephrosis were included. Pre- and postoperative (after completion of compensatory hypertrophy) parenchymal volumes were calculated using Synapse Vincent, Fujifilm and compared regional increasing ratio in each area (total parenchyma, cortex and medulla).

Results

Mean preoperative volume of total kidney, cortex and medulla were 181.95 (31.38) ml, 112.53 (25.57) ml and 67.40 (16.85) ml and mean postoperative one were 200.81 (41.65) ml, 126.66 (34.94) ml and 74.15 (16.81) ml, respectively. Cortex volume increases significantly comparing to the preoperative status (p=0.04); however, medulla volume and cortex-medulla volume ratio did not change significantly. Body mass index, gender and preoperative estimated glomerular filtration ratio (eGFR) did not affect the cortex hypertrophy. When comparing the cortex increasing ratio to the change in eGFR, cortex hypertrophy indicated fewer decline in eGFR (fig: p=0.2, R=0.41).

Conclusion

Within the small preliminary experience, computational volume-analysis indicated kidney volume increase after nephrectomy in the cortex region superiority to the medulla. Cortex hypertrophy might correlate with better preservation of renal function in eGFR.