Abstract: FR-PO558

Incidental Risk of Hypertension According to the Change of Body Weight (BW) in Korean Men

Session Information

Category: Hypertension

  • 1105 Hypertension: Clinical and Translational - Genetics and Epigenetics

Authors

  • Park, Sung keun, Kangbuk Samsung Hospital, Sungkyunkwan University, School of medicine, Seoul, Kore, Seoul, Korea (the Republic of)
  • Lee, Dong-Young, None, Seoul, Korea (the Republic of)
Background

Despite accumulated evidence of strong relationship between obesity and hypertension, risk for hypertension according to the change of BW is not clearly identified. Therefore, this study was to evaluate the incidental risk of hypertension according to the change of BW.

Methods

26,483 normotensive Korean men had been followed up from 2005 to 2010. Based on baseline BW in 2005, the changes of BW [(BW at censoring time – BW at baseline)/follow-up period (person-years)] were categorized into 5 groups according to their change levels from the lowest to the highest quintile (Q) (1st – 5thQ). On the base of 3rd Q, 1st and 2nd Q had negative changes of BW, and 4th and 5th Q had positive changes of BW. Cox proportional hazard models was used to evaluate the effect of BW change on the incidental risk of hypertension.

Results

During follow-up, 4,445 (16.8 %) cases of hypertension newly developed (Q 1-5: 19.0 ,12.9, 12.4, 14.8, and 24.8% respectively). When quintile 3 was set as a reference in adjusted model, the hazard ratios (HRs) for incidental hypertension exhibited a J-shaped relationship with the BW changes (Q1: 1.66 [95% confidence interval (CI): 1.41–1.95], Q2: 0.96 [95% CI: 0.80–1.14], Q3: 1.00 [reference], Q4: 1.30 [95% CI: 1.10–1.54], and Q5: 3.39 [95% CI: 2.91–3.96], respectively).

Conclusion

The incidental risk of hypertension increased in weight loss as well as weight gain, which demonstrated J-shaped relationship. This finding warrants further studies to investigate the incidental relationship between BW changes and hypertension.