Abstract: SA-PO168

Exercise Favorably Affects Renal Function in Metabolic Syndrome without CKD: A Prospective Single-Center Study

Session Information

Category: Nutrition, Inflammation, and Metabolism

  • 1401 Nutrition, Inflammation, Metabolism

Authors

  • Ueda, Atsushi, Tsukuba University Hospital Hitachi Medical Education and Research Center, Hitachi, Ibaraki, Japan
  • Nagai, Kei, University of Tsukuba hospital, Tsukuba-city Ibaraki, Japan
  • Hirayama, Aki, Tsukuba University of Technology, Tsukuba, Japan
  • Saito, Chie, University of Tsukuba, Tsukuba, Japan
  • Yamagata, Kunihiro, University of Tsukuba, Tsukuba, Japan
Background

A high body mass index (BMI) predicts an onset of CKD in population with normal renal function (Kidney Int. 2017; 91:1224-1235). It is expected that lifestyle-modification in obese individuals without CKD has favorable effects on renal function through the normalization of body weight and BMI. However, whether exercise can improve the renal function in obese individuals without drug-medications has not been fully resolved.

Methods

We studied 29 patients with high BMI (>25 kg/m2) and/or hypertensive (>grade 1 hypertension) and/or high LDL-C (>140 mg/dL) and/or moderately high HbA1c (6.5–7.5%), with no abnormality of urinalysis and no drug-medications. We provided education regarding resistance-exercise and aerobic exercise to the subjects for one hour at the first (baseline) visit. We measured their weight, waist circumference, blood pressure, and laboratory data at every visit. In addition, step-counts per day were calculated from cumulative records for every day by the pedometer during visits.

Results

Compared to first (baseline, visit 1), one month (visit 2), and two month later (visit 3), the mean step-counts of the subjects tend to increase (P=0.07, Fig 1A). The mean body weight and BMI were 71.9, 70.8 and 69.3 kg (P<0.01), and 26.4, 26.0, and 25.6 kg/m2 (P<0.01, Fig 1B), respectively. Changes in step-counts and that in body weight were negatively correlated (r=-0.51, P=0.01). While serum LDL-C and HbA1c were not significantly declined, serum creatinine (P=0.01) and eGFR (P=0.01, Fig 1C) were improved during the follow-up.

Conclusion

Though the changes in most of parameters (blood pressure, lipid status and glycemic status) were not significant in this limited follow-up time, significant changes in renal function (serum creatinine and eGFR) were identified. It is suggested that exercise among obese individuals has a potential to improve their renal function independent of drug-medications.