Abstract: SA-PO169

Protein Energy Wasting Is Correlated with Irisin and Over Load Fluid in Peritoneal Dialysis Patients

Session Information

Category: Nutrition, Inflammation, and Metabolism

  • 1401 Nutrition, Inflammation, Metabolism

Authors

  • Zhou, Sijia, Peking University Third Hospital, Beijing, China
  • Zhang, Ai Hua, Peking University Third Hospital, Beijing, China
Background

Protein energy wasting (PEW) is a common phenomenon in maintenance dialysis patients and increased morbidity and mortality. The mechanisms are unclear. Over load fluid may also induce PEW in peritoneal dialysis patients. Irisin is a newly discovered myokine which can alleviate insulin risistance, is one kind of regulators of energy homeostasis and metabolism in humans. The aim of this study is to assess the relationships between irisin, over load fluid and PEW in PD patients.

Methods

This study is a cross-sectional study with 160 patients on maintenance peritoneal dialysis in peritoneal dialysis center of Peking University Third Hospital involved and 35 healthy people in a control group. PD patients were divided into two groups: protein energy waste group (PEW group) and non-protein energy waste group (non-PEW group) according to PEW diagnosis criteria. Serum irisin concentrations were measured by ELISA methods. The body composition consisting of over load fluid status [over hydration (OH) value >=2)] was analyzed by bioelectrical impedance.

Results

The serum irisin levels were significantly lower in PD patients compared with controls [113.2±11.8ng/ml vs. 464.2±37.4ng/ml, P<0.01]. The serum irisin levels were lower in PD patients with protein energy wasting than those of the patients without protein energy wasting[107.8±9.6ng/ml vs. 119.0±11.3ng/ml, P<0.01]. Existing over load fluid patients with higher prevalence of PEW (59.8%Vs.40.2%, x2=6.223, P=0.013). But there was no direct relationship between irisin level and over load fluid. The independent determinants of PEW were serum irisin and serum albumin.

Conclusion

Our results provide clinical evidence of the association between irisin, over load fluid and protein energy wasting in PD patients. Low irisin and over load fluid may aggravate protein energy wasting.

Funding

  • Government Support - Non-U.S.